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Olfactory Detection of Toluene by Detection Rats for Potential Screening of Lung Cancer
 
 
Article

Multi-Odor Discrimination by Rat Sniffing for Potential Monitoring of Lung Cancer and Diabetes

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Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) 125 Gwahang-ro, Yuseong-gu, Daejeon 34141, Korea
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Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Sungbuk-gu, Seoul 02841, Korea
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Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) 125 Gwahang-ro, Yuseong-gu, Daejeon 34141, Korea
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Department of Physiology and Biophysics, Eulji University School of Medicine, 77 Gyeryong-ro, Jung-gu, Daejeon 34824, Korea
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KRIBB School, Korea University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Rawil Fakhrullin
Sensors 2021, 21(11), 3696; https://doi.org/10.3390/s21113696
Received: 19 April 2021 / Revised: 20 May 2021 / Accepted: 21 May 2021 / Published: 26 May 2021
(This article belongs to the Special Issue Living Biosensors for Odor Detection)
The discrimination learning of multiple odors, in which multi-odor can be associated with different responses, is important for responding quickly and accurately to changes in the external environment. However, very few studies have been done on multi-odor discrimination by animal sniffing. Herein, we report a novel multi-odor discrimination system by detection rats based on the combination of 2-Choice and Go/No-Go (GNG) tasks into a single paradigm, in which the Go response of GNG was replaced by 2-Choice, for detection of toluene and acetone, which are odor indicators of lung cancer and diabetes, respectively. Three of six trained rats reached performance criterion, in 12 consecutive successful tests within a given set or over 12 sets with a success rate of over 90%. Through a total of 1300 tests, the trained animals (N = 3) showed multi-odor sensing performance with 88% accuracy, 87% sensitivity and 90% specificity. In addition, a dependence of behavior response time on odor concentrations under given concentration conditions was observed, suggesting that the system could be used for quantitative measurements. Furthermore, the animals’ multi-odor sensing performance has lasted for 45 days, indicating long-term stability of the learned multi-odor discrimination. These findings demonstrate that multi-odor discrimination can be achieved by rat sniffing, potentially providing insight into the rapid, accurate and cost-effective multi-odor monitoring in the lung cancer and diabetes. View Full-Text
Keywords: multi-odor discrimination; 2-choice/no-go; animal biosensor; olfactory behavior multi-odor discrimination; 2-choice/no-go; animal biosensor; olfactory behavior
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MDPI and ACS Style

Oh, Y.; Kwon, O.; Min, S.-S.; Shin, Y.-B.; Oh, M.-K.; Kim, M. Multi-Odor Discrimination by Rat Sniffing for Potential Monitoring of Lung Cancer and Diabetes. Sensors 2021, 21, 3696. https://doi.org/10.3390/s21113696

AMA Style

Oh Y, Kwon O, Min S-S, Shin Y-B, Oh M-K, Kim M. Multi-Odor Discrimination by Rat Sniffing for Potential Monitoring of Lung Cancer and Diabetes. Sensors. 2021; 21(11):3696. https://doi.org/10.3390/s21113696

Chicago/Turabian Style

Oh, Yunkwang, Ohseok Kwon, Sun-Seek Min, Yong-Beom Shin, Min-Kyu Oh, and Moonil Kim. 2021. "Multi-Odor Discrimination by Rat Sniffing for Potential Monitoring of Lung Cancer and Diabetes" Sensors 21, no. 11: 3696. https://doi.org/10.3390/s21113696

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