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Article

Cu2O/PEDOT:PSS/ZnO Nanocomposite Material Biosensor for Esophageal Cancer Detection

1
Department of Medicine, Mackay Medical College, 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei 25245, Taiwan
2
Department of Dermatology, Chung Shan Medical University and Chung Shan Medical University Hospital, No.110, Sec. 1, Jianguo N. Rd., South Dist., Taichung City 40201, Taiwan
3
Department of Mechanical Engineering and Advanced Institute of Manufacturing with High Tech Innovations, National Chung Cheng University, 168, University Rd., Min Hsiung, Chia Yi 62102, Taiwan
4
Department of Otolaryngology, Kaohsiung Armed Forced General Hospital, 2, Zhongzheng 1st. Rd., Lingya District, Kaohsiung City 80284, Taiwan
*
Authors to whom correspondence should be addressed.
Sensors 2020, 20(9), 2455; https://doi.org/10.3390/s20092455
Received: 5 March 2020 / Revised: 15 April 2020 / Accepted: 24 April 2020 / Published: 26 April 2020
(This article belongs to the Special Issue Nanomaterials for Environmental and Biological Monitoring)
A highly sensitive photoelectrochemical (PEC) biosensor without external bias was developed in this study. The biosensor was configured with a p-Cu2O and n-ZnO heterostructure. Hexamethylenetetramine (HMTA) and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) was used to improve the crystal structure of Cu2O and ZnO and reduce the defects in the Cu2O/ZnO interface. This fabrication method provided the highly crystallized Cu2O/ZnO structure with excellent electrical property and photoresponse in visible light. The structure was applied to a biosensor for detecting two different cancerous levels of esophageal cells, namely, OE21 and OE21-1, with a high gain in photocurrent (5.8 and 6.2 times, respectively) and a low detection limit (3000 cells in 50 μL). We believe that such a p-n heterojunction PEC biosensor could advance biosensor development and provide a promising candidate for biomedical applications. View Full-Text
Keywords: biosensor; esophageal cancer; photoelectrochemical; semiconductor heterostructure biosensor; esophageal cancer; photoelectrochemical; semiconductor heterostructure
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MDPI and ACS Style

Tseng, K.-W.; Hsiao, Y.-P.; Jen, C.-P.; Chang, T.-S.; Wang, H.-C. Cu2O/PEDOT:PSS/ZnO Nanocomposite Material Biosensor for Esophageal Cancer Detection. Sensors 2020, 20, 2455. https://doi.org/10.3390/s20092455

AMA Style

Tseng K-W, Hsiao Y-P, Jen C-P, Chang T-S, Wang H-C. Cu2O/PEDOT:PSS/ZnO Nanocomposite Material Biosensor for Esophageal Cancer Detection. Sensors. 2020; 20(9):2455. https://doi.org/10.3390/s20092455

Chicago/Turabian Style

Tseng, Kuang-Wen, Yu-Ping Hsiao, Chun-Ping Jen, Tsung-Shun Chang, and Hsiang-Chen Wang. 2020. "Cu2O/PEDOT:PSS/ZnO Nanocomposite Material Biosensor for Esophageal Cancer Detection" Sensors 20, no. 9: 2455. https://doi.org/10.3390/s20092455

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