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Noble Metal-Assisted Surface Plasmon Resonance Immunosensors

by Jin-Ha Choi 1,†, Jin-Ho Lee 2,†, Joohyung Son 1 and Jeong-Woo Choi 1,3,*
1
Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04107, Korea
2
School of Biomedical Convergence Engineering, Pusan National University, Yangsan 50612, Korea
3
Department of Biomedical Engineering, Sogang University, Seoul 04107, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Sensors 2020, 20(4), 1003; https://doi.org/10.3390/s20041003 (registering DOI)
Received: 21 January 2020 / Revised: 5 February 2020 / Accepted: 11 February 2020 / Published: 13 February 2020
(This article belongs to the Special Issue Optical Immunosensors)
For the early diagnosis of several diseases, various biomarkers have been discovered and utilized through the measurement of concentrations in body fluids such as blood, urine, and saliva. The most representative analytical method for biomarker detection is an immunosensor, which exploits the specific antigen-antibody immunoreaction. Among diverse analytical methods, surface plasmon resonance (SPR)-based immunosensors are emerging as a potential detection platform due to high sensitivity, selectivity, and intuitive features. Particularly, SPR-based immunosensors could detect biomarkers without labeling of a specific detection probe, as typical immunosensors such as enzyme-linked immunosorbent assay (ELISA) use enzymes like horseradish peroxidase (HRP). In this review, SPR-based immunosensors utilizing noble metals such as Au and Ag as SPR-inducing factors for the measurement of different types of protein biomarkers, including viruses, microbes, and extracellular vesicles (EV), are briefly introduced. View Full-Text
Keywords: surface plasmon resonance; noble nanoparticle; immunosensor; label-free detection; biosensor surface plasmon resonance; noble nanoparticle; immunosensor; label-free detection; biosensor
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MDPI and ACS Style

Choi, J.-H.; Lee, J.-H.; Son, J.; Choi, J.-W. Noble Metal-Assisted Surface Plasmon Resonance Immunosensors. Sensors 2020, 20, 1003.

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