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Open AccessArticle

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

1
Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland
2
Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, A. Abrahama 58, 80-307 Gdańsk, Poland
3
Centre de recherche en photonique, Université du Québec en Outaouais, 101 rue Saint-Jean-Bosco, Gatineau, QC J8X 3X7, Canada
4
Baltic Institute of Technology, Al. Zwycięstwa 96/98, 81-451 Gdynia, Poland
5
Warsaw University of Technology, Institute of Microelectronics and Optoelectronics, 00-662 Koszykowa 75, Warsaw, Poland
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(3), 813; https://doi.org/10.3390/s20030813
Received: 10 December 2019 / Revised: 22 January 2020 / Accepted: 30 January 2020 / Published: 3 February 2020
(This article belongs to the Special Issue Long Period Fiber Grating Based Sensors and Components)
Since the norovirus is the main cause of acute gastroenteritis all over the world, its fast detection is crucial in medical diagnostics. In this work, a rapid, sensitive, and selective optical fiber biosensor for the detection of norovirus virus-like particles (VLPs) is reported. The sensor is based on highly sensitive long-period fiber gratings (LPFGs) coated with antibodies against the main coat protein of the norovirus. Several modification methods were verified to obtain reliable immobilization of protein receptors on the LPFG surface. We were able to detect 1 ng/mL norovirus VLPs in a 40-min assay in a label-free manner. Thanks to the application of an optical fiber as the sensor, there is a possibility to increase the user’s safety by separating the measurement point from the signal processing setup. Moreover, our sensor is small and light, and the proposed assay is straightforward. The designed LPFG-based biosensor could be applied in both fast norovirus detection and in vaccine testing. View Full-Text
Keywords: virus detection; norovirus; virus-like particle; label-free biosensor; optical fiber sensor; long-period fiber gratings virus detection; norovirus; virus-like particle; label-free biosensor; optical fiber sensor; long-period fiber gratings
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Janczuk-Richter, M.; Gromadzka, B.; Richter, Ł.; Panasiuk, M.; Zimmer, K.; Mikulic, P.; Bock, W.J.; Maćkowski, S.; Śmietana, M.; Niedziółka Jönsson, J. Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis. Sensors 2020, 20, 813.

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