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DNA Origami-Enabled Biosensors

by 1,2,†, 2,†, 2, 2, 1,2, 1,*, 3 and 2,4
1
Institute of Marine Biomedicine, Shenzhen Polytechnic, Shenzhen 518055, China
2
State Key Laboratory of Analytical Chemistry for Life Science, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210023, China
3
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
4
Shenzhen Research Institute of Nanjing University, Shenzhen 518000, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Sensors 2020, 20(23), 6899; https://doi.org/10.3390/s20236899
Received: 23 November 2020 / Accepted: 30 November 2020 / Published: 3 December 2020
(This article belongs to the Special Issue Chemical Sciences in Nanjing University: 100th Anniversary)
Biosensors are small but smart devices responding to the external stimulus, widely used in many fields including clinical diagnosis, healthcare and environment monitoring, etc. Moreover, there is still a pressing need to fabricate sensitive, stable, reliable sensors at present. DNA origami technology is able to not only construct arbitrary shapes in two/three dimension but also control the arrangement of molecules with different functionalities precisely. The functionalization of DNA origami nanostructure endows the sensing system potential of filling in weak spots in traditional DNA-based biosensor. Herein, we mainly review the construction and sensing mechanisms of sensing platforms based on DNA origami nanostructure according to different signal output strategies. It will offer guidance for the application of DNA origami structures functionalized by other materials. We also point out some promising directions for improving performance of biosensors. View Full-Text
Keywords: DNA origami; sensor; DNA nanotechnology; FRET; chirality; SERS; nanopore DNA origami; sensor; DNA nanotechnology; FRET; chirality; SERS; nanopore
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MDPI and ACS Style

Wang, S.; Zhou, Z.; Ma, N.; Yang, S.; Li, K.; Teng, C.; Ke, Y.; Tian, Y. DNA Origami-Enabled Biosensors. Sensors 2020, 20, 6899. https://doi.org/10.3390/s20236899

AMA Style

Wang S, Zhou Z, Ma N, Yang S, Li K, Teng C, Ke Y, Tian Y. DNA Origami-Enabled Biosensors. Sensors. 2020; 20(23):6899. https://doi.org/10.3390/s20236899

Chicago/Turabian Style

Wang, Shuang; Zhou, Zhaoyu; Ma, Ningning; Yang, Sichang; Li, Kai; Teng, Chao; Ke, Yonggang; Tian, Ye. 2020. "DNA Origami-Enabled Biosensors" Sensors 20, no. 23: 6899. https://doi.org/10.3390/s20236899

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