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Article

Hybrid Sensor Device for Simultaneous Surface Plasmon Resonance and Surface Acoustic Wave Measurements

1
Institute of Molecular Biology & Biotechnology, FO.R.T.H, Vassilika Vouton, 70013 Heraklion, Greece
2
Department of Biology, University of Crete, Vassilika Vouton, 71409 Heraklion, Greece
3
Institute of Electronic Structure & Laser, FO.R.T.H, Vassilika Vouton, 71409 Heraklion, Greece
4
SENSeOR SAS, Time and Frequency Department, FEMTO-ST Institute, 15B Avenue des Montboucons, 25030 Besançon, France
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(21), 6177; https://doi.org/10.3390/s20216177
Received: 29 September 2020 / Revised: 23 October 2020 / Accepted: 26 October 2020 / Published: 29 October 2020
(This article belongs to the Section Biosensors)
Surface plasmon resonance (SPR) and Love wave (LW) surface acoustic wave (SAW) sensors have been established as reliable biosensing technologies for label-free, real-time monitoring of biomolecular interactions. This work reports the development of a combined SPR/LW-SAW platform to facilitate simultaneous optical and acoustic measurements for the investigation of biomolecules binding on a single surface. The system’s output provides recordings of two acoustic parameters, phase and amplitude of a Love wave, synchronized with SPR readings. We present the design and manufacturing of a novel experimental set-up employing, in addition to the SPR/LW-SAW device, a 3D-printed plastic holder combined with a PDMS microfluidic cell so that the platform can be used in a flow-through mode. The system was evaluated in a systematic study of the optical and acoustic responses for different surface perturbations, i.e., rigid mass loading (Au deposition), pure viscous loading (glycerol and sucrose solutions) and protein adsorption (BSA). Our results provide the theoretical and experimental basis for future application of the combined system to other biochemical and biophysical studies. View Full-Text
Keywords: biosensors; surface plasmon resonance; surface acoustic wave; Love wave; combined SPR/LW-SAW biosensing platform; 3D printing; PDMS microfluidics; protein adsorption biosensors; surface plasmon resonance; surface acoustic wave; Love wave; combined SPR/LW-SAW biosensing platform; 3D printing; PDMS microfluidics; protein adsorption
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MDPI and ACS Style

Samarentsis, A.G.; Pantazis, A.K.; Tsortos, A.; Friedt, J.-M.; Gizeli, E. Hybrid Sensor Device for Simultaneous Surface Plasmon Resonance and Surface Acoustic Wave Measurements. Sensors 2020, 20, 6177. https://doi.org/10.3390/s20216177

AMA Style

Samarentsis AG, Pantazis AK, Tsortos A, Friedt J-M, Gizeli E. Hybrid Sensor Device for Simultaneous Surface Plasmon Resonance and Surface Acoustic Wave Measurements. Sensors. 2020; 20(21):6177. https://doi.org/10.3390/s20216177

Chicago/Turabian Style

Samarentsis, Anastasios G., Alexandros K. Pantazis, Achilleas Tsortos, Jean-Michel Friedt, and Electra Gizeli. 2020. "Hybrid Sensor Device for Simultaneous Surface Plasmon Resonance and Surface Acoustic Wave Measurements" Sensors 20, no. 21: 6177. https://doi.org/10.3390/s20216177

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