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Letter

A Point-of-Care Based on Label-Free Interferometric Optical Detection Method to Evaluate Interferon Gamma (IFN-γ): A Correlation with the ELISA Technique

1
Center for Biomedical Technology, Optics, Photonics and Biophotonics Lab., Universidad Politécnica de Madrid, Campus Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain
2
Department of Applied Physics and Materials Engineering, Escuela Técnica Superior de Ingenieros Industriales, Universidad Politécnica de Madrid, C/José Gutierrez Abascal 2, 28006 Madrid, Spain
3
BioOptical Detection SL, Centro de Empresas, Campus Montegancedo, 28223 Madrid, Spain
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(17), 4776; https://doi.org/10.3390/s20174776
Received: 1 July 2020 / Revised: 10 August 2020 / Accepted: 21 August 2020 / Published: 24 August 2020
(This article belongs to the Section Optical Sensors)
Interferon-gamma (IFN-γ) is a cytokine associated with inflammatory diseases, virus, infection, etc. The quantification of interferon-gamma concentration levels is studied to relate the immune system response to the progression of disease. In this work, we used a label-free point-of-care device based on the increase relative optical power (IROP) and a biosensor based on photonic transducers called BICELLs (Biophotonic Sensing Cells) to evaluate interferon-gamma concentrations. The BICELLs’ sensing surface size used is 100 μm in diameter. The bioreceptor is attached to the surface by streptavidin-biotin affinity. This label-free IROP-based device can work with a low concentration of reagents and a low sample volume for measurements. Furthermore, this new device was compared with an ELISA technique in the same conditions. A good correlation was achieved between both techniques. This device is easy to use, and it is a cost-effective tool for monitoring an analyte in a disease. View Full-Text
Keywords: point-of-care; label-free detection; interferometric optical detection; interferon gamma; ELISA technique point-of-care; label-free detection; interferometric optical detection; interferon gamma; ELISA technique
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MDPI and ACS Style

Heras, M.F.L.; Ramirez, Y.; Fernández Martín, C.; L. Espinosa, R.; Lavín, A.; Holgado, M. A Point-of-Care Based on Label-Free Interferometric Optical Detection Method to Evaluate Interferon Gamma (IFN-γ): A Correlation with the ELISA Technique. Sensors 2020, 20, 4776. https://doi.org/10.3390/s20174776

AMA Style

Heras MFL, Ramirez Y, Fernández Martín C, L. Espinosa R, Lavín A, Holgado M. A Point-of-Care Based on Label-Free Interferometric Optical Detection Method to Evaluate Interferon Gamma (IFN-γ): A Correlation with the ELISA Technique. Sensors. 2020; 20(17):4776. https://doi.org/10.3390/s20174776

Chicago/Turabian Style

Heras, María Fe Laguna, Yolanda Ramirez, Celia Fernández Martín, Rocío L. Espinosa, Alvaro Lavín, and Miguel Holgado. 2020. "A Point-of-Care Based on Label-Free Interferometric Optical Detection Method to Evaluate Interferon Gamma (IFN-γ): A Correlation with the ELISA Technique" Sensors 20, no. 17: 4776. https://doi.org/10.3390/s20174776

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