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Open AccessArticle

Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles

by 1,2,*,† and 3,*,†
1
Department of Electromechanical, Systems and Metal Engineering, Ghent University, 9052 Zwijnaarde, Belgium
2
Cancer Research Institute Ghent, 9000 Ghent, Belgium
3
Department of Solid State Sciences, Ghent University, 9000 Ghent, Belgium
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Sensors 2020, 20(14), 3882; https://doi.org/10.3390/s20143882
Received: 7 June 2020 / Revised: 1 July 2020 / Accepted: 9 July 2020 / Published: 12 July 2020
(This article belongs to the Special Issue Electromagnetic Sensors for Biomedical Applications)
Magnetic nanoparticles are increasingly employed in biomedical applications such as disease detection and tumor treatment. To ensure a safe and efficient operation of these applications, a noninvasive and accurate characterization of the particles is required. In this work, a magnetic characterization technique is presented in which the particles are excited by specific pulsed time-varying magnetic fields. This way, we can selectively excite nanoparticles of a given size so that the resulting measurement gives direct information on the size distribution without the need for any a priori assumptions or complex postprocessing procedures to decompose the measurement signal. This contrasts state-of-the-art magnetic characterization techniques. The possibility to selectively excite certain particle types opens up perspectives in “multicolor” particle imaging, where different particle types need to be imaged independently within one sample. Moreover, the presented methodology allows one to simultaneously determine the size-dependent coercivity of the particles. This is not only a valuable structure–property relation from a fundamental point of view, it is also practically relevant to optimize applications like magnetic particle hyperthermia. We numerically demonstrate that the novel characterization technique can accurately reconstruct several particle size distributions and is able to retrieve the coercivity–size relation of the particles. The developed technique advances current magnetic nanoparticle characterization possibilities and opens up exciting pathways for biomedical applications and particle imaging procedures. View Full-Text
Keywords: magnetorelaxometry; magnetic nanopartices; micromagnetism; nanomagnetism; magnetic dynamics; characterization; size distribution; coercivity; magnetic particle imaging; magnetic particle hyperthermia magnetorelaxometry; magnetic nanopartices; micromagnetism; nanomagnetism; magnetic dynamics; characterization; size distribution; coercivity; magnetic particle imaging; magnetic particle hyperthermia
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MDPI and ACS Style

Coene, A.; Leliaert, J. Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles. Sensors 2020, 20, 3882. https://doi.org/10.3390/s20143882

AMA Style

Coene A, Leliaert J. Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles. Sensors. 2020; 20(14):3882. https://doi.org/10.3390/s20143882

Chicago/Turabian Style

Coene, Annelies; Leliaert, Jonathan. 2020. "Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles" Sensors 20, no. 14: 3882. https://doi.org/10.3390/s20143882

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