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Open AccessLetter

Stone Paper as a New Substrate to Fabricate Flexible Screen-Printed Electrodes for the Electrochemical Detection of Dopamine

1
National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, No. 67–103, RO, 400293 Cluj-Napoca, Romania
2
NANOM MEMS srl, G. Cosbuc Street, No. 9, RO, 505400 Rasnov, Brasov, Romania
3
Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Street, 060021 Bucharest-6, Romania
4
Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 060042 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(12), 3609; https://doi.org/10.3390/s20123609
Received: 25 May 2020 / Revised: 16 June 2020 / Accepted: 23 June 2020 / Published: 26 June 2020
(This article belongs to the Special Issue Graphene-Based Sensors for Pharmaceutical and Biomedical Analysis)
Flexible screen-printed electrodes (HP) were fabricated on stone paper substrate and amperometrically modified with gold nanoparticles (HP-AuNPs). The modified electrode displayed improved electronic transport properties, reflected in a low charge-transfer resistance (1220 Ω) and high apparent heterogeneous electron transfer rate constant (1.94 × 10−3 cm/s). The voltammetric detection of dopamine (DA) was tested with HP and HP-AuNPs electrodes in standard laboratory solutions (pH 6 phosphate-buffered saline (PBS)) containing various concentrations of analyte (10−7–10−3 M). As expected, the modified electrode exhibits superior performances in terms of linear range (10−7–10−3 M) and limit of detection (3 × 10−8 M), in comparison with bare HP. The determination of DA was tested with HP-AuNPs in spiked artificial urine and in pharmaceutical drug solution (ZENTIVA) that contained dopamine hydrochloride (5 mg/mL). The results obtained indicated a very good DA determination in artificial urine without significant matrix effects. In the case of the pharmaceutical drug solution, the DA determination was affected by the interfering species present in the vial, such as sodium metabisulfite, maleic acid, sodium chloride, and propylene glycol. View Full-Text
Keywords: flexible screen-printed electrodes; stone paper; gold nanoparticles; dopamine detection flexible screen-printed electrodes; stone paper; gold nanoparticles; dopamine detection
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Varodi, C.; Pogacean, F.; Gheorghe, M.; Mirel, V.; Coros, M.; Barbu-Tudoran, L.; Stefan-van Staden, R.-I.; Pruneanu, S. Stone Paper as a New Substrate to Fabricate Flexible Screen-Printed Electrodes for the Electrochemical Detection of Dopamine. Sensors 2020, 20, 3609.

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