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Open AccessArticle

CdTe Quantum Dots Modified with Cysteamine: A New Efficient Nanosensor for the Determination of Folic Acid

1
Tecnológico Nacional de México/Instituto Tecnológico de Tijuana, Centro de Graduados e Investigación, A.P. 1166, Tijuana 22500, Mexico
2
Miami Dade College, North Campus, 11380 NW 27th Ave, Miami, FL 33167, USA
3
Centro de Investigación en Materiales Avanzados S. C., Departamento de Física de Materiales, Av. Miguel de Cervantes 120, Complejo Industrial Chihuahua, Chihuahua CP 31136, Mexico
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(20), 4548; https://doi.org/10.3390/s19204548
Received: 13 September 2019 / Revised: 12 October 2019 / Accepted: 15 October 2019 / Published: 19 October 2019
(This article belongs to the Special Issue Fluorescence-Based Sensors)
In this paper, we report the synthesis, characterization, and application of a new fluorescent nanosensor based on water-soluble CdTe quantum dots (QDs) coated with cysteamine (CA) for the determination of folic acid (FA). CdTe/CA QDs were characterized by high-resolution transmission electron microscopy, the zeta potential, and Fourier-transform infrared (FT-IR), UV-visible, and fluorescence spectroscopy. CdTe QDs coated with mercaptopropionic acid (MPA) and glutathione (GSH) were prepared for comparison purposes. The effect of FA on the photoluminescence intensity of the three thiol-capped QDs at pH 8 was studied. Only CdTe/CA QDs showed a notable fluorescence quenching in the presence of FA. Then, a nanosensor based on the fluorescence quenching of the CdTe QDs at pH 8 was explored. Under optimum conditions, the calibration curve showed a linear fluorescence quenching response in a concentration range of FA from 0.16 to 16.4 μM (R2 = 0.9944), with a detection limit of 0.048 μM. A probable mechanism of fluorescence quenching was proposed. The nanosensor showed good selectivity over other possible interferences. This method has been applied for FA quantification in orange beverage samples with excellent results (recoveries from 98.3 to 103.9%). The good selectivity, sensitivity, low cost, and rapidity make CdTe /CA QDs a suitable nanosensor for FA determination. View Full-Text
Keywords: folic acid nanosensor; positive quantum dots; fluorescence quenching; electron transfer folic acid nanosensor; positive quantum dots; fluorescence quenching; electron transfer
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MDPI and ACS Style

Ramírez-Herrera, D.E.; Reyes-Cruzaley, A.P.; Dominguez, G.; Paraguay-Delgado, F.; Tirado-Guízar, A.; Pina-Luis, G. CdTe Quantum Dots Modified with Cysteamine: A New Efficient Nanosensor for the Determination of Folic Acid. Sensors 2019, 19, 4548. https://doi.org/10.3390/s19204548

AMA Style

Ramírez-Herrera DE, Reyes-Cruzaley AP, Dominguez G, Paraguay-Delgado F, Tirado-Guízar A, Pina-Luis G. CdTe Quantum Dots Modified with Cysteamine: A New Efficient Nanosensor for the Determination of Folic Acid. Sensors. 2019; 19(20):4548. https://doi.org/10.3390/s19204548

Chicago/Turabian Style

Ramírez-Herrera, Doris E.; Reyes-Cruzaley, Ana P.; Dominguez, Giselle; Paraguay-Delgado, Francisco; Tirado-Guízar, Antonio; Pina-Luis, Georgina. 2019. "CdTe Quantum Dots Modified with Cysteamine: A New Efficient Nanosensor for the Determination of Folic Acid" Sensors 19, no. 20: 4548. https://doi.org/10.3390/s19204548

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