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Open AccessArticle

Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical Sensing

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Institute of Quantum Optics, Gottfried Wilhelm Leibniz University Hannover, 30167 Hannover, Germany
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Lower Saxony Centre for Biomedical Engineering, Implant Research and Development (NIFE), 30625 Hannover, Germany
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Industrial and Biomedical Optics Department, Laser Zentrum Hannover e.V., 30419 Hannover, Germany
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School of Integrated Design Engineering, Keio University, Yokohama 223-8522, Japan
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Hannover Centre for Optical Technologies, Gottfried Wilhelm Leibniz University Hannover, 30167 Hannover, Germany
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Cluster of Excellence PhoenixD (Photonics, Optics and Engineering-Innovation Across Disciplines), 30167 Hannover, Germany
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(19), 4333; https://doi.org/10.3390/s19194333
Received: 4 September 2019 / Revised: 27 September 2019 / Accepted: 27 September 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Integrated Photonics for Novel Sensing and Measurement Applications)
Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices. View Full-Text
Keywords: waveguide; microfluidics; fluorescence; hydrogels; 3D printing waveguide; microfluidics; fluorescence; hydrogels; 3D printing
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Torres-Mapa, M.L.; Singh, M.; Simon, O.; Mapa, J.L.; Machida, M.; Günther, A.; Roth, B.; Heinemann, D.; Terakawa, M.; Heisterkamp, A. Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical Sensing. Sensors 2019, 19, 4333.

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