Next Article in Journal
Logarithmic Strain Model for Nonlinear Load Cell
Previous Article in Journal
A Contention-Based Hop-By-Hop Bidirectional Congestion Control Algorithm for Ad-Hoc Networks
Previous Article in Special Issue
Molecularly Imprinted Polymer Based Sensors for Medical Applications
Article Menu

Export Article

Open AccessReview

Evaluation of Molecularly Imprinted Polymers for Point-of-Care Testing for Cardiovascular Disease

1
School of Biotechnology, Dublin City University, Dublin 9, Ireland
2
Research Complex, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(16), 3485; https://doi.org/10.3390/s19163485
Received: 18 July 2019 / Revised: 29 July 2019 / Accepted: 6 August 2019 / Published: 9 August 2019
(This article belongs to the Special Issue Imprinting Technology for Advanced Point-of-Care Sensing)
  |  
PDF [9977 KB, uploaded 9 August 2019]
  |  

Abstract

Molecular imprinting is a rapidly growing area of interest involving the synthesis of artificial recognition elements that enable the separation of analyte from a sample matrix and its determination. Traditionally, this approach can be successfully applied to small analyte (<1.5 kDa) separation/ extraction, but, more recently it is finding utility in biomimetic sensors. These sensors consist of a recognition element and a transducer similar to their biosensor counterparts, however, the fundamental distinction is that biomimetic sensors employ an artificial recognition element. Molecularly imprinted polymers (MIPs) employed as the recognition elements in biomimetic sensors contain binding sites complementary in shape and functionality to their target analyte. Despite the growing interest in molecularly imprinting techniques, the commercial adoption of this technology is yet to be widely realised for blood sample analysis. This review aims to assess the applicability of this technology for the point-of-care testing (POCT) of cardiovascular disease-related biomarkers. More specifically, molecular imprinting is critically evaluated with respect to the detection of cardiac biomarkers indicative of acute coronary syndrome (ACS), such as the cardiac troponins (cTns). The challenges associated with the synthesis of MIPs for protein detection are outlined, in addition to enhancement techniques that ultimately improve the analytical performance of biomimetic sensors. The mechanism of detection employed to convert the analyte concentration into a measurable signal in biomimetic sensors will be discussed. Furthermore, the analytical performance of these sensors will be compared with biosensors and their potential implementation within clinical settings will be considered. In addition, the most suitable application of these sensors for cardiovascular assessment will be presented. View Full-Text
Keywords: point-of-care; cardiovascular disease; biomimetic sensors; molecularly imprinted polymers; cardiac biomarker; biomarker detection point-of-care; cardiovascular disease; biomimetic sensors; molecularly imprinted polymers; cardiac biomarker; biomarker detection
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Regan, B.; Boyle, F.; O’Kennedy, R.; Collins, D. Evaluation of Molecularly Imprinted Polymers for Point-of-Care Testing for Cardiovascular Disease. Sensors 2019, 19, 3485.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top