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Electrochemical Sensing of α-Fetoprotein Based on Molecularly Imprinted Polymerized Ionic Liquid Film on a Gold Nanoparticle Modified Electrode Surface

1
Institute of Food Science and Engineering Technology, Hezhou University, Hezhou 542899, China
2
Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Sensors 2019, 19(14), 3218; https://doi.org/10.3390/s19143218
Received: 28 May 2019 / Revised: 24 June 2019 / Accepted: 16 July 2019 / Published: 22 July 2019
(This article belongs to the Section Chemical Sensors)
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Abstract

A molecularly imprinted sensor was fabricated for alpha-fetoprotein (AFP) using an ionic liquid as a functional monomer. Ionic liquid possesses many excellent characteristics which can improve the sensing performances of the imprinted electrochemical sensor. To demonstrate this purpose, 1-[3-(N-cystamine)propyl]-3-vinylimidazolium tetrafluoroborate ionic liquid [(Cys)VIMBF4] was synthesized and used as a functional monomer to fabricate an AFP imprinted polymerized ionic liquid film on a gold nanoparticle modified glassy carbon electrode (GCE) surface at room temperature. After removing the AFP template, a molecularly imprinted electrochemical sensor was successfully prepared. The molecularly imprinted sensor exhibits excellent selectivity towards AFP, and can be used for sensitive determination of AFP. Under the optimized conditions, the imprinted sensor shows a good linear response to AFP in the concentration range of 0.03 ng mL−1~5 ng mL−1. The detection limit is estimated to be 2 pg mL−1. View Full-Text
Keywords: molecularly imprinted; α-fetoprotein; ionic liquid; gold nanoparticles molecularly imprinted; α-fetoprotein; ionic liquid; gold nanoparticles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wu, Y.; Wang, Y.; Wang, X.; Wang, C.; Li, C.; Wang, Z. Electrochemical Sensing of α-Fetoprotein Based on Molecularly Imprinted Polymerized Ionic Liquid Film on a Gold Nanoparticle Modified Electrode Surface. Sensors 2019, 19, 3218.

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