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Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions

Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, Poland
Department of Nephrology, Transplantology and Internal Diseases, Faculty of Medicine, Medical University of Gdańsk, 3a Marii Skłodowskiej-Curie Street, 80-210 Gdansk, Poland
Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, 159 Nowoursynowska Street, 02-776 Warszawa, Poland
Authors to whom correspondence should be addressed.
Sensors 2018, 18(7), 2001;
Received: 15 May 2018 / Revised: 19 June 2018 / Accepted: 20 June 2018 / Published: 22 June 2018
(This article belongs to the Special Issue Spectroscopy Based Sensors)
PDF [2334 KB, uploaded 22 June 2018]


In this paper, an investigation into detecting immunosuppressive medicine in aqueous solutions using a spectrometry-based technique is described. Using optical transmissive spectrometry, absorbance measurements in the spectra range from 250 nm to 1000 nm were carried out for different cyclosporine A (CsA) concentrations in aqueous solutions. The experiment was conducted for samples both with and without interferent substances—glucose and sodium chloride. Using a dedicated algorithm, the measured data was analyzed and a high correlation coefficient R2 = 0.8647 was achieved. The experiment showed that the described technique allowed for the detection of various CsA concentration levels in a selective, label-free and simple way. This method could be used in medicine, veterinary medicine and laboratory diagnostics. View Full-Text
Keywords: optical spectrophotometry; label-free detection; cyclosporine optical spectrophotometry; label-free detection; cyclosporine

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Marzejon, M.; Kosowska, M.; Majchrowicz, D.; Bułło-Piontecka, B.; Wąsowicz, M.; Jędrzejewska-Szczerska, M. Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions. Sensors 2018, 18, 2001.

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