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PCANet-Based Structural Representation for Nonrigid Multimodal Medical Image Registration

Department of Biomedical Engineering, School of Life Science and Technology, Ministry of Education Key Laboratory of Molecular Biophysics, Huazhong University of Science and Technology, No. 1037, Luoyu Road, Wuhan 430074, China
State Food and Drug Administration Hubei Center for Medical Devices Quality Supervision and Testing, No. 507, Hi-Tech Avenue, Donghu Hi-Tech Development District, Wuhan 430075, China
Author to whom correspondence should be addressed.
Sensors 2018, 18(5), 1477;
Received: 30 March 2018 / Revised: 4 May 2018 / Accepted: 5 May 2018 / Published: 8 May 2018
(This article belongs to the Special Issue Sensor Signal and Information Processing)
PDF [5992 KB, uploaded 17 May 2018]


Nonrigid multimodal image registration remains a challenging task in medical image processing and analysis. The structural representation (SR)-based registration methods have attracted much attention recently. However, the existing SR methods cannot provide satisfactory registration accuracy due to the utilization of hand-designed features for structural representation. To address this problem, the structural representation method based on the improved version of the simple deep learning network named PCANet is proposed for medical image registration. In the proposed method, PCANet is firstly trained on numerous medical images to learn convolution kernels for this network. Then, a pair of input medical images to be registered is processed by the learned PCANet. The features extracted by various layers in the PCANet are fused to produce multilevel features. The structural representation images are constructed for two input images based on nonlinear transformation of these multilevel features. The Euclidean distance between structural representation images is calculated and used as the similarity metrics. The objective function defined by the similarity metrics is optimized by L-BFGS method to obtain parameters of the free-form deformation (FFD) model. Extensive experiments on simulated and real multimodal image datasets show that compared with the state-of-the-art registration methods, such as modality-independent neighborhood descriptor (MIND), normalized mutual information (NMI), Weber local descriptor (WLD), and the sum of squared differences on entropy images (ESSD), the proposed method provides better registration performance in terms of target registration error (TRE) and subjective human vision. View Full-Text
Keywords: medical image registration; PCANet; structural representation; similarity metric; target registration error medical image registration; PCANet; structural representation; similarity metric; target registration error

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Zhu, X.; Ding, M.; Huang, T.; Jin, X.; Zhang, X. PCANet-Based Structural Representation for Nonrigid Multimodal Medical Image Registration. Sensors 2018, 18, 1477.

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