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Open AccessArticle

Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure

by Fei Li 1,2, Deyu Li 3,* and Fei Yan 1,2,*
1
Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
2
Shenzhen Key Laboratory of Ultrasound Imaging and Therapy, Shenzhen 518055, China
3
School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
*
Authors to whom correspondence should be addressed.
This paper is an extended version of our paper published in Enhanced ambient pressure sensitivity of the subharmonic signal from ultrasound contrast microbubbles. In Proceedings of the 2013 IEEE International Ultrasonics Symposium (IUS), Prague, Czech Republic, 21−25 July 2013.
Sensors 2018, 18(12), 4083; https://doi.org/10.3390/s18124083
Received: 31 October 2018 / Revised: 14 November 2018 / Accepted: 19 November 2018 / Published: 22 November 2018
(This article belongs to the Special Issue Ultrasonic Sensors 2018)
Microbubbles are considered a promising tool for noninvasive estimation of local blood pressure. It is reported that the subharmonic scattering amplitude of microbubbles decreases by 9 to 12 dB when immersed in the media under an ambient pressure variation from 0 to 180 mmHg. However, the pressure sensitivity still needs to be improved to satisfy clinical diagnostic requirements. Here, we investigated the effects of acoustic parameters on the pressure sensitivity of microbubbles through measuring the acoustic attenuation and scattering properties of commercially available SonoVue microbubbles. Our results showed that the first harmonic, subharmonic, and ultraharmonic amplitudes of microbubbles were reduced by 6.6 dB, 10.9 dB, and 9.3 dB at 0.225 mechanical index (MI), 4.6 dB, 19.8 dB, and 12.3 dB at 0.25 MI, and 18.5 dB, 17.6 dB, and 12.6 dB at 0.3 MI, respectively, when the ambient pressure increased from 0 to 180 mmHg. Our finding revealed that a moderate MI (0.25–0.4) exciting microbubbles could significantly improve their sensitivities to detect ambient pressure. View Full-Text
Keywords: microbubbles; pressure sensors; noninvasive blood pressure measurement; mechanical index; subharmonic amplitude microbubbles; pressure sensors; noninvasive blood pressure measurement; mechanical index; subharmonic amplitude
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Li, F.; Li, D.; Yan, F. Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure. Sensors 2018, 18, 4083.

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