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Article

Toward High Throughput Core-CBCM CMOS Capacitive Sensors for Life Science Applications: A Novel Current-Mode for High Dynamic Range Circuitry

1
Department of Electrical and Computer Engineering, Isfahan University of Technology, 84156-83111 Isfahan, Iran
2
Biologically Inspired Sensors and Actuators (BioSA), Department of Electrical Engineering and Computer Science (EECS), Lassonde School of Engineering, York University, Toronto, ON M3J 1P3, Canada
*
Author to whom correspondence should be addressed.
Sensors 2018, 18(10), 3370; https://doi.org/10.3390/s18103370
Received: 25 August 2018 / Revised: 27 September 2018 / Accepted: 5 October 2018 / Published: 9 October 2018
This paper proposes a novel charge-based Complementary Metal Oxide Semiconductor (CMOS) capacitive sensor for life science applications. Charge-based capacitance measurement (CBCM) has significantly attracted the attention of researchers for the design and implementation of high-precision CMOS capacitive biosensors. A conventional core-CBCM capacitive sensor consists of a capacitance-to-voltage converter (CVC), followed by a voltage-to-digital converter. In spite of their high accuracy and low complexity, their input dynamic range (IDR) limits the advantages of core-CBCM capacitive sensors for most biological applications, including cellular monitoring. In this paper, after a brief review of core-CBCM capacitive sensors, we address this challenge by proposing a new current-mode core-CBCM design. In this design, we combine CBCM and current-controlled oscillator (CCO) structures to improve the IDR of the capacitive readout circuit. Using a 0.18 μm CMOS process, we demonstrate and discuss the Cadence simulation results to demonstrate the high performance of the proposed circuitry. Based on these results, the proposed circuit offers an IDR ranging from 873 aF to 70 fF with a resolution of about 10 aF. This CMOS capacitive sensor with such a wide IDR can be employed for monitoring cellular and molecular activities that are suitable for biological research and clinical purposes. View Full-Text
Keywords: CMOS; capacitive sensor; CBCM; dynamic range; bioengineering CMOS; capacitive sensor; CBCM; dynamic range; bioengineering
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MDPI and ACS Style

Forouhi, S.; Dehghani, R.; Ghafar-Zadeh, E. Toward High Throughput Core-CBCM CMOS Capacitive Sensors for Life Science Applications: A Novel Current-Mode for High Dynamic Range Circuitry. Sensors 2018, 18, 3370. https://doi.org/10.3390/s18103370

AMA Style

Forouhi S, Dehghani R, Ghafar-Zadeh E. Toward High Throughput Core-CBCM CMOS Capacitive Sensors for Life Science Applications: A Novel Current-Mode for High Dynamic Range Circuitry. Sensors. 2018; 18(10):3370. https://doi.org/10.3390/s18103370

Chicago/Turabian Style

Forouhi, Saghi; Dehghani, Rasoul; Ghafar-Zadeh, Ebrahim. 2018. "Toward High Throughput Core-CBCM CMOS Capacitive Sensors for Life Science Applications: A Novel Current-Mode for High Dynamic Range Circuitry" Sensors 18, no. 10: 3370. https://doi.org/10.3390/s18103370

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