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Sensors 2017, 17(8), 1737;

Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications

Department of Electronics and Electromagnetism, Faculty of Physics, University of Seville, Av. Reina Mercedes sn, Seville 41012, Spain
Group of Microelectronics Engineering, Department of Electronics Technology, Systems Engineering and Automation, University of Cantabria, Santander 39005, Spain
Seville Institute of Microelectronics, Microelectronics National Center, Consejo Superior de Investigaciones Científicas (IMSE-CNM-CSIC), Av. Americo Vespuccio, sn, Seville 41092, Spain
Computer Engineering School (ETSII), University of Seville, Av. Reina Mercedes sn, Seville 41012, Spain
Author to whom correspondence should be addressed.
Academic Editor: Nicole Jaffrezic-Renault
Received: 19 May 2017 / Revised: 17 July 2017 / Accepted: 25 July 2017 / Published: 28 July 2017
(This article belongs to the Section Biosensors)
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To follow up the restenosis in arteries stented during an angioplasty is an important current clinical problem. A new approach to monitor the growth of neointimal tissue inside the stent is proposed on the basis of electrical impedance spectroscopy (EIS) sensors and the oscillation-based test (OBT) circuit technique. A mathematical model was developed to analytically describe the histological composition of the neointima, employing its conductivity and permittivity data. The bioimpedance model was validated against a finite element analysis (FEA) using COMSOL Multiphysics software. A satisfactory correlation between the analytical model and FEA simulation was achieved in most cases, detecting some deviations introduced by the thin “double layer” that separates the neointima and the blood. It is hereby shown how to apply conformal transformations to obtain bioimpedance electrical models for stack-layered tissues over coplanar electrodes. Particularly, this can be applied to characterize the neointima in real-time. This technique is either suitable as a main mechanism for restenosis follow-up or it can be combined with proposed intelligent stents for blood pressure measurements to auto-calibrate the sensibility loss caused by the adherence of the tissue on the micro-electro-mechanical sensors (MEMSs). View Full-Text
Keywords: bioimpedance; atherosclerosis; cardiology; oscillation-based test; stent bioimpedance; atherosclerosis; cardiology; oscillation-based test; stent

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Rivas-Marchena, D.; Olmo, A.; Miguel, J.A.; Martínez, M.; Huertas, G.; Yúfera, A. Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications. Sensors 2017, 17, 1737.

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