Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate

Ouyang, Lei; Jiang, Zuyan; Wang, Nan; Zhu, Lihua; Tang, Heqing

doi:10.3390/s17071601

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Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate

by

Lei Ouyang

^1,2,†,

Zuyan Jiang

^1,†,

Nan Wang

¹,

Lihua Zhu

^1,* and

Heqing Tang

^2,*

¹

School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

²

Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission and Ministry of Education, College of Resources and Environmental Science, South Central University for Nationalities, Wuhan 430074, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contribute equally to this work.

Sensors 2017, 17(7), 1601; https://doi.org/10.3390/s17071601

Submission received: 21 May 2017 / Revised: 17 June 2017 / Accepted: 20 June 2017 / Published: 10 July 2017

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing)

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Abstract

Sibutramine hydrochloride (SH) is a banned weight-loss drug, but its illegal addition to health products is still rampant. This suggests a very urgent need for a fast and precise detection method for SH. Surface Enhanced Raman Scattering (SERS) is a promising candidate for this purpose, but the weak affinity between SH and bare metal limits its direct SERS detection. In the present work, β-cyclodextrin was capped in situ onto the surface of Ag nanoparticles to function as a scaffold to capture SH. The obtained Ag nanoparticles were encapsulated into polyvinyl alcohol (PVA) to fabricate a SERS active hydrogel with excellent reproducibility. A facile SERS strategy based on such substrate was proposed for trace SH quantification with a linear range of 7.0–150.0 µg·mL^–1, and a detection limit low to 3.0 µg·mL⁻¹. It was applied to analyze seven types of commercial slimming capsules with satisfactory results, showing good prospect for real applications.

Keywords: sibutramine hydrochloride; Surface Enhanced Raman Scattering; β-cyclodextrin; polyvinyl alcohol

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MDPI and ACS Style

Ouyang, L.; Jiang, Z.; Wang, N.; Zhu, L.; Tang, H. Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate. Sensors 2017, 17, 1601. https://doi.org/10.3390/s17071601

AMA Style

Ouyang L, Jiang Z, Wang N, Zhu L, Tang H. Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate. Sensors. 2017; 17(7):1601. https://doi.org/10.3390/s17071601

Chicago/Turabian Style

Ouyang, Lei, Zuyan Jiang, Nan Wang, Lihua Zhu, and Heqing Tang. 2017. "Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate" Sensors 17, no. 7: 1601. https://doi.org/10.3390/s17071601

APA Style

Ouyang, L., Jiang, Z., Wang, N., Zhu, L., & Tang, H. (2017). Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate. Sensors, 17(7), 1601. https://doi.org/10.3390/s17071601

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Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate

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