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Sensors 2017, 17(4), 810;

Miniaturized FDDA and CMOS Based Potentiostat for Bio-Applications

LABioTRON Bioeng. Research Laboratory, ECE Dept. Université Laval, Québec City, QC G1V 0A6, Canada
Ophthalmology Department, Faculty of Medicine, Université Laval, Québec City, QC G1V 0A6, Canada
CoFaMic, Université du Québec à Montréal, Montreal, QC H2L 2C4, Canada
Biomedical Microsystems Laboratory, ECE Dept. Université Laval, Québec City, QC G1V 0A6, Canada
Author to whom correspondence should be addressed.
Academic Editors: Stephane Evoy and Baris Fidan
Received: 18 February 2017 / Revised: 4 April 2017 / Accepted: 8 April 2017 / Published: 10 April 2017
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Canada 2017)
Full-Text   |   PDF [2247 KB, uploaded 25 April 2017]   |  


A novel fully differential difference CMOS potentiostat suitable for neurotransmitter sensing is presented. The described architecture relies on a fully differential difference amplifier (FDDA) circuit to detect a wide range of reduction-oxidation currents, while exhibiting low-power consumption and low-noise operation. This is made possible thanks to the fully differential feature of the FDDA, which allows to increase the source voltage swing without the need for additional dedicated circuitry. The FDDA also reduces the number of amplifiers and passive elements in the potentiostat design, which lowers the overall power consumption and noise. The proposed potentiostat was fabricated in 0.18 µm CMOS, with 1.8 V supply voltage. The device achieved 5 µA sensitivity and 0.99 linearity. The input-referred noise was 6.9 µV rms and the flicker noise was negligible. The total power consumption was under 55 µW. The complete system was assembled on a 20 mm × 20 mm platform that includes the potentiostat chip, the electrode terminals and an instrumentation amplifier for redox current buffering, once converted to a voltage by a series resistor. the chip dimensions were 1 mm × 0.5 mm and the other PCB components were off-chip resistors, capacitors and amplifiers for data acquisition. The system was successfully tested with ferricyanide, a stable electroactive compound, and validated with dopamine, a popular neurotransmitter. View Full-Text
Keywords: electrochemical sensor; electronics; integration electrochemical sensor; electronics; integration

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ghodsevali, E.; Morneau-Gamache, S.; Mathault, J.; Landari, H.; Boisselier, É.; Boukadoum, M.; Gosselin, B.; Miled, A. Miniaturized FDDA and CMOS Based Potentiostat for Bio-Applications. Sensors 2017, 17, 810.

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