Next Article in Journal
Proof of Concept: Development of Snow Liquid Water Content Profiler Using CS650 Reflectometers at Caribou, ME, USA
Next Article in Special Issue
Molecular Imprinting Applications in Forensic Science
Previous Article in Journal
Efficient and Security Enhanced Anonymous Authentication with Key Agreement Scheme in Wireless Sensor Networks
Previous Article in Special Issue
Imprinting Technology in Electrochemical Biomimetic Sensors

Ultratrace Detection of Histamine Using a Molecularly-Imprinted Polymer-Based Voltammetric Sensor

Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö SE-20506, Sweden
Author to whom correspondence should be addressed.
Academic Editor: Alexander Star
Sensors 2017, 17(3), 645;
Received: 6 February 2017 / Revised: 9 March 2017 / Accepted: 17 March 2017 / Published: 21 March 2017
(This article belongs to the Special Issue Biosensors and Molecular Imprinting)
Rapid and cost-effective analysis of histamine, in food, environmental, and diagnostics research has been of interest recently. However, for certain applications, the already-existing biological receptor-based sensing methods have usage limits in terms of stability and costs. As a result, robust and cost-effective imprinted polymeric receptors can be the best alternative. In the present work, molecularly-imprinted polymers (MIPs) for histamine were synthesized using methacrylic acid in chloroform and acetonitrile as two different porogens. The binding affinity of the MIPs with histamine was evaluated in aqueous media. MIPs synthesized in chloroform displayed better imprinting properties for histamine. We demonstrate here histamine MIPs incorporated into a carbon paste (CP) electrode as a MIP-CP electrode sensor platforms for detection of histamine. This simple sensor format allows accurate determination of histamine in the sub-nanomolar range using an electrochemical method. The sensor exhibited two distinct linear response ranges of 1 × 10−10–7 × 10−9 M and 7 × 10−9–4 × 10−7 M. The detection limit of the sensor was calculated equal to 7.4 × 10−11 M. The specificity of the proposed electrode for histamine is demonstrated by using the analogous molecules and other neurotransmitters such as serotonin, dopamine, etc. The MIP sensor was investigated with success on spiked serum samples. The easy preparation, simple procedure, and low production cost make the MIP sensor attractive for selective and sensitive detection of analytes, even in less-equipped laboratories with minimal training. View Full-Text
Keywords: histamine imprinted polymers; Ultratraces; sensor histamine imprinted polymers; Ultratraces; sensor
Show Figures

Figure 1

MDPI and ACS Style

Akhoundian, M.; Rüter, A.; Shinde, S. Ultratrace Detection of Histamine Using a Molecularly-Imprinted Polymer-Based Voltammetric Sensor. Sensors 2017, 17, 645.

AMA Style

Akhoundian M, Rüter A, Shinde S. Ultratrace Detection of Histamine Using a Molecularly-Imprinted Polymer-Based Voltammetric Sensor. Sensors. 2017; 17(3):645.

Chicago/Turabian Style

Akhoundian, Maedeh, Axel Rüter, and Sudhirkumar Shinde. 2017. "Ultratrace Detection of Histamine Using a Molecularly-Imprinted Polymer-Based Voltammetric Sensor" Sensors 17, no. 3: 645.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop