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Sensors 2017, 17(10), 2300; https://doi.org/10.3390/s17102300

Biosensing Using Magnetic Particle Detection Techniques

Department of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204, USA
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Received: 2 July 2017 / Revised: 26 August 2017 / Accepted: 30 August 2017 / Published: 10 October 2017
(This article belongs to the Special Issue GMR and TMR Sensors)
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Abstract

Magnetic particles are widely used as signal labels in a variety of biological sensing applications, such as molecular detection and related strategies that rely on ligand-receptor binding. In this review, we explore the fundamental concepts involved in designing magnetic particles for biosensing applications and the techniques used to detect them. First, we briefly describe the magnetic properties that are important for bio-sensing applications and highlight the associated key parameters (such as the starting materials, size, functionalization methods, and bio-conjugation strategies). Subsequently, we focus on magnetic sensing applications that utilize several types of magnetic detection techniques: spintronic sensors, nuclear magnetic resonance (NMR) sensors, superconducting quantum interference devices (SQUIDs), sensors based on the atomic magnetometer (AM), and others. From the studies reported, we note that the size of the MPs is one of the most important factors in choosing a sensing technique. View Full-Text
Keywords: magnetic particles; spintronic sensors; GMR; NMR; SQUID; atomic magnetometer; molecular sensing magnetic particles; spintronic sensors; GMR; NMR; SQUID; atomic magnetometer; molecular sensing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chen, Y.-T.; Kolhatkar, A.G.; Zenasni, O.; Xu, S.; Lee, T.R. Biosensing Using Magnetic Particle Detection Techniques. Sensors 2017, 17, 2300.

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