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Sensors 2017, 17(1), 217;

Hierarchical NiCo2O4 Hollow Sphere as a Peroxidase Mimetic for Colorimetric Detection of H2O2 and Glucose

State Key Laboratory of Marine Resource Utilization in South China Sea, Key Laboratory of Tropical Biological Resources of Ministry of Education Hainan University, College of Material and Chemical Engineering, Haikou 570228, China
Laboratory Cultivation Base of Natural Gas Conversion, School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China
Author to whom correspondence should be addressed.
Academic Editors: Jong Seung Kim and Min Hee Lee
Received: 6 December 2016 / Revised: 9 January 2017 / Accepted: 16 January 2017 / Published: 23 January 2017
(This article belongs to the Special Issue Colorimetric and Fluorescent Sensor)
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In this work, the hierarchical NiCo2O4 hollow sphere synthesized via a “coordinating etching and precipitating” process was demonstrated to exhibit intrinsic peroxidase-like activity. The peroxidase-like activity of NiCo2O4, NiO, and Co3O4 hollow spheres were comparatively studied by the catalytic oxidation reaction of 3,3,5,5-tetramethylbenzidine (TMB) in presence of H2O2, and a superior peroxidase-like activity of NiCo2O4 was confirmed by stronger absorbance at 652 nm. Furthermore, the proposed sensing platform showed commendable response to H2O2 with a linear range from 10 μM to 400 μM, and a detection limit of 0.21 μM. Cooperated with GOx, the developed novel colorimetric and visual glucose-sensing platform exhibited high selectivity, favorable reproducibility, satisfactory applicability, wide linear range (from 0.1 mM to 4.5 mM), and a low detection limit of 5.31 μM. In addition, the concentration-dependent color change would offer a better and handier way for detection of H2O2 and glucose by naked eye. View Full-Text
Keywords: NiCo2O4; hierarchical hollow sphere; peroxidase-like; colorimetric NiCo2O4; hierarchical hollow sphere; peroxidase-like; colorimetric

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Huang, W.; Lin, T.; Cao, Y.; Lai, X.; Peng, J.; Tu, J. Hierarchical NiCo2O4 Hollow Sphere as a Peroxidase Mimetic for Colorimetric Detection of H2O2 and Glucose. Sensors 2017, 17, 217.

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