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Open AccessArticle

A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures

Kazi Institute of Chemistry, University of Sindh, Jamshoro 76080, Pakistan
Department of Metallurgy and Material Science, Mehran University of Engineering and Technology, Jamshoro 76080, Pakistan
National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan
Department of Science and Technology, Campus Norrkoping, Linkoping University, Norrkoping SE-60174, Sweden
Authors to whom correspondence should be addressed.
Academic Editors: Giovanni Sparacino, Andrea Facchinetti and J. Hans DeVries
Sensors 2016, 16(11), 1878;
Received: 21 August 2016 / Revised: 1 November 2016 / Accepted: 4 November 2016 / Published: 14 November 2016
(This article belongs to the Special Issue Glucose Sensors: Revolution in Diabetes Management 2016)
The production of a nanomaterial with enhanced and desirable electrocatalytic properties is of prime importance, and the commercialization of devices containing these materials is a challenging task. In this study, unique cupric oxide (CuO) nanostructures were synthesized using lysine as a soft template for the evolution of morphology via a rapid and boiled hydrothermal method. The morphology and structure of the synthesized CuO nanomaterial were characterized using scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively. The prepared CuO nanostructures showed high potential for use in the electrocatalytic oxidation of glucose in an alkaline medium. The proposed enzyme-free glucose sensor demonstrated a robust response to glucose with a wide linear range and high sensitivity, selectivity, stability, and reproducibility. To explore its practical feasibility, the glucose content of serum samples was successfully determined using the enzyme-free sensor. An analytical recovery method was used to measure the actual glucose from the serum samples, and the results were satisfactory. Moreover, the presented glucose sensor has high chemical stability and can be reused for repetitive measurements. This study introduces an enzyme-free glucose sensor as an alternative tool for clinical glucose quantification. View Full-Text
Keywords: CuO nanostructures; lysine; glucose sensor; electrochemical techniques CuO nanostructures; lysine; glucose sensor; electrochemical techniques
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Baloach, Q.-U.-A.; Tahira, A.; Mallah, A.B.; Abro, M.I.; Uddin, S.; Willander, M.; Ibupoto, Z.H. A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures. Sensors 2016, 16, 1878.

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