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Biomedical Probes Based on Inorganic Nanoparticles for Electrochemical and Optical Spectroscopy Applications
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Toward Epileptic Brain Region Detection Based on Magnetic Nanoparticle Patterning

Departement of Mechanical Engineering, Sharif University of Technology, Tehran, Iran
Departement of Electrical Engineering and Computer Science, York University, Toronto, ON M3J1P3, Canada
Authors to whom correspondence should be addressed.
Academic Editor: Shinya Maenosono
Sensors 2015, 15(9), 24409-24427;
Received: 15 May 2015 / Revised: 2 September 2015 / Accepted: 14 September 2015 / Published: 22 September 2015
(This article belongs to the Special Issue Inorganic Nanoparticles as Biomedical Probes)
PDF [1293 KB, uploaded 22 September 2015]


Resection of the epilepsy foci is the best treatment for more than 15% of epileptic patients or 50% of patients who are refractory to all forms of medical treatment. Accurate mapping of the locations of epileptic neuronal networks can result in the complete resection of epileptic foci. Even though currently electroencephalography is the best technique for mapping the epileptic focus, it cannot define the boundary of epilepsy that accurately. Herein we put forward a new accurate brain mapping technique using superparamagnetic nanoparticles (SPMNs). The main hypothesis in this new approach is the creation of super-paramagnetic aggregates in the epileptic foci due to high electrical and magnetic activities. These aggregates may improve tissue contrast of magnetic resonance imaging (MRI) that results in improving the resection of epileptic foci. In this paper, we present the mathematical models before discussing the simulation results. Furthermore, we mimic the aggregation of SPMNs in a weak magnetic field using a low-cost microfabricated device. Based on these results, the SPMNs may play a crucial role in diagnostic epilepsy and the subsequent treatment of this disease. View Full-Text
Keywords: epilepsy; brain magnetic field; magnetic nanoparticle epilepsy; brain magnetic field; magnetic nanoparticle

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Pedram, M.Z.; Shamloo, A.; Alasty, A.; Ghafar-Zadeh, E. Toward Epileptic Brain Region Detection Based on Magnetic Nanoparticle Patterning. Sensors 2015, 15, 24409-24427.

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