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Open AccessArticle

Label-Free, Single Molecule Resonant Cavity Detection: A Double-Blind Experimental Study

Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, 3651 Watt Way, Los Angeles, CA 90089, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: M. Selim Ünlü
Sensors 2015, 15(3), 6324-6341;
Received: 11 November 2014 / Revised: 27 February 2015 / Accepted: 5 March 2015 / Published: 16 March 2015
(This article belongs to the Special Issue Advances in Optical Biosensors)
Optical resonant cavity sensors are gaining increasing interest as a potential diagnostic method for a range of applications, including medical prognostics and environmental monitoring. However, the majority of detection demonstrations to date have involved identifying a “known” analyte, and the more rigorous double-blind experiment, in which the experimenter must identify unknown solutions, has yet to be performed. This scenario is more representative of a real-world situation. Therefore, before these devices can truly transition, it is necessary to demonstrate this level of robustness. By combining a recently developed surface chemistry with integrated silica optical sensors, we have performed a double-blind experiment to identify four unknown solutions. The four unknown solutions represented a subset or complete set of four known solutions; as such, there were 256 possible combinations. Based on the single molecule detection signal, we correctly identified all solutions. In addition, as part of this work, we developed noise reduction algorithms. View Full-Text
Keywords: biosensors; optical resonators; single molecule detection biosensors; optical resonators; single molecule detection
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Chistiakova, M.V.; Shi, C.; Armani, A.M. Label-Free, Single Molecule Resonant Cavity Detection: A Double-Blind Experimental Study. Sensors 2015, 15, 6324-6341.

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