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Open AccessArticle

Liver Cancer Detection by a Simple, Inexpensive and Effective Immunosensor with Zinc Oxide Nanoparticles

Department of Electrical Engineering, National Chi Nan University, Nantou 54561, Taiwan
Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan
Department of Physics and Electronic Engineering, University of Science (Vietnam National University of Hochiminh City), District 5, Hochiminh City 999100, Vietnam
Department of Pediatrics, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Department of Electronics Engineering, Nan Kai University of Technology, Nantou 54243, Taiwan
Department of Biotechnology, Asia University, Taichung 41354, Taiwan
Division of Science & Technology, Hong Kong Community College, Hong Kong, China
Authors to whom correspondence should be addressed.
Academic Editor: Frances S. Ligler
Sensors 2015, 15(11), 29408-29418;
Received: 23 September 2015 / Revised: 9 November 2015 / Accepted: 13 November 2015 / Published: 20 November 2015
(This article belongs to the Section Biosensors)
Regular monitoring of blood α-fetoprotein (AFP) and/or carcino-embryonic antigen (CEA) levels is important for the routine screening of liver cancer. However, AFP and CEA have a much lower specificity than des-γ-carboxyprothrombin (DCP) to detect liver cancer. Therefore, the study reported here was designed, to develop a screen-printed DCP immunosensor incorporating zinc oxide nanoparticles, for accurate determination of DCP. The designed immunosensor shows low detection limits for the detection of DCP: 0.440 ng/mL (based on impedance measurement), 0.081 ng/mL (based on real part of impedance measurement) and 0.078 ng/mL (based on imaginary part of impedance measurement), within the range of 3.125 ng/mL to 2000 ng/mL. In addition, there was little interference to DCP determination by molecules such as Na+, K+, Ca2+, Cl, glucose, urea, and uric acid. It is therefore concluded that the DCP immunosensor developed and reported here is simple, inexpensive and effective, and shows promise in the rapid screening of early-stage liver cancer at home with a point-of-care approach. View Full-Text
Keywords: liver cancer; DCP; immunosensor; screening; nanoparticle liver cancer; DCP; immunosensor; screening; nanoparticle
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Ching, C.T.-S.; Van Hieu, N.; Cheng, T.-Y.; Fu, L.-S.; Sun, T.-P.; Liu, M.-Y.; Huang, S.-H.; Yao, Y.-D. Liver Cancer Detection by a Simple, Inexpensive and Effective Immunosensor with Zinc Oxide Nanoparticles. Sensors 2015, 15, 29408-29418.

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