Sensors 2014, 14(8), 13592-13612; https://doi.org/10.3390/s140813592
Virus Outbreaks in Chemical and Biological Sensors
The Research Institute of Basic Sciences, Seoul National University, Seoul 147-779, Korea
Received: 18 April 2014 / Revised: 8 July 2014 / Accepted: 8 July 2014 / Published: 25 July 2014
(This article belongs to the Section Biosensors)
Abstract
Filamentous bacteriophages have successfully been used to detect chemical and biological analytes with increased selectivity and sensitivity. The enhancement largely originates not only from the ability of viruses to provide a platform for the surface display of a wide range of biological ligands, but also from the geometric morphologies of the viruses that constitute biomimetic structures with larger surface area-to-volume ratio. This review will appraise the mechanism of multivalent display of the viruses that enables surface modification of virions either by chemical or biological methods. The accommodation of functionalized virions to various materials, including polymers, proteins, metals, nanoparticles, and electrodes for sensor applications will also be discussed. View Full-TextKeywords:
virus; biosensor; phage display; biomimetic
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Hwang, I. Virus Outbreaks in Chemical and Biological Sensors. Sensors 2014, 14, 13592-13612.