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Sensors 2013, 13(5), 5777-5795;

Microbial Biosensors: Engineered Microorganisms as the Sensing Machinery

Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan
Author to whom correspondence should be addressed.
Received: 11 March 2013 / Revised: 18 April 2013 / Accepted: 3 May 2013 / Published: 6 May 2013
(This article belongs to the Special Issue Live Cell-Based Sensors)
Full-Text   |   PDF [1868 KB, uploaded 21 June 2014]


Whole-cell biosensors are a good alternative to enzyme-based biosensors since they offer the benefits of low cost and improved stability. In recent years, live cells have been employed as biosensors for a wide range of targets. In this review, we will focus on the use of microorganisms that are genetically modified with the desirable outputs in order to improve the biosensor performance. Different methodologies based on genetic/protein engineering and synthetic biology to construct microorganisms with the required signal outputs, sensitivity, and selectivity will be discussed. View Full-Text
Keywords: synthetic biology; scaffolds; genetic circuits synthetic biology; scaffolds; genetic circuits
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Park, M.; Tsai, S.-L.; Chen, W. Microbial Biosensors: Engineered Microorganisms as the Sensing Machinery. Sensors 2013, 13, 5777-5795.

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