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Sensors 2012, 12(12), 16420-16432;

Applications of Surface Plasmon Resonance (SPR) for the Characterization of Nanoparticles Developed for Biomedical Purposes

Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano 20156, Italy
Department of Experimental Medicine, University of Milano Bicocca, Monza 20052, Italy
Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Milano 20131, Italy
Author to whom correspondence should be addressed.
Received: 18 September 2012 / Revised: 30 October 2012 / Accepted: 22 November 2012 / Published: 27 November 2012
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Italy 2012)
Full-Text   |   PDF [278 KB, uploaded 21 June 2014]


Great interest is currently being devoted to the development of nanoparticles (NPs) for biomedical purposes, designed to improve the pharmacokinetic profile of their cargos (either imaging probes or drugs) and to enhance the specific targeting at the disease site. Recent works suggest that Surface Plasmon Resonance (SPR), widely used for the analysis of biomolecular interactions, represents a technique of choice for rapid and quantitative analyses of the interaction between NPs—functionalized with specific ligands—and their putative biological targets. Moreover, SPR can provide important details on the formation and the role of the protein “corona”, i.e., the protein layer which coats NPs once they come into contact with biological fluids. These novel applications of SPR sensors may be very useful to characterize, screen and develop nanodevices for biomedical purposes. View Full-Text
Keywords: nanoparticles; surface plasmon resonance; protein corona nanoparticles; surface plasmon resonance; protein corona
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Canovi, M.; Lucchetti, J.; Stravalaci, M.; Re, F.; Moscatelli, D.; Bigini, P.; Salmona, M.; Gobbi, M. Applications of Surface Plasmon Resonance (SPR) for the Characterization of Nanoparticles Developed for Biomedical Purposes. Sensors 2012, 12, 16420-16432.

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