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Short Note

Methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate

1
Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 18, 31000 Osijek, Croatia
2
Faculty of Chemistry and Technology, University of Split, R. Boškovića 35, 21000 Split, Croatia
*
Author to whom correspondence should be addressed.
Academic Editor: R. Alan Aitken
Molbank 2022, 2022(3), M1434; https://doi.org/10.3390/M1434
Received: 2 August 2022 / Revised: 22 August 2022 / Accepted: 23 August 2022 / Published: 25 August 2022
A green synthetic procedure was developed for the two-step synthesis of methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate from anthranilic acid, using two green chemistry approaches: utilization of the DES and microwave-induced synthesis. The first step includes a synthesis of 2-mercapto-3-(3-methoxyphenyl)quinazolin-4(3H)-one which was performed in choline chloride:urea DES. In the second step S-alkylation of 2-mercapto-3-(3-methoxyphenyl)quinazolin-4(3H)-one was performed in a microwave-induced reaction. The desired compound was successfully obtained in a yield of 59% and was characterized by different spectral methods. View Full-Text
Keywords: quinazolinone; green chemistry; alkylation quinazolinone; green chemistry; alkylation
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MDPI and ACS Style

Molnar, M.; Komar, M.; Jerković, I. Methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate. Molbank 2022, 2022, M1434. https://doi.org/10.3390/M1434

AMA Style

Molnar M, Komar M, Jerković I. Methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate. Molbank. 2022; 2022(3):M1434. https://doi.org/10.3390/M1434

Chicago/Turabian Style

Molnar, Maja, Mario Komar, and Igor Jerković. 2022. "Methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate" Molbank 2022, no. 3: M1434. https://doi.org/10.3390/M1434

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