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Molbank
Volume 2022
Issue 3
10.3390/M1404
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4-(4-(((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-7-chloroquinoline

by
Leong Ka Fai
1,
Margrate Anyanwu
2,
Jiang Ai
1,
Yuhan Xie
1,
Alessandra Gianoncelli
2,
Giovanni Ribaudo
2,* and
Paolo Coghi
1,*
1
School of Pharmacy, Macau University of Science and Technology, Macau, China
2
Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Nicholas E. Leadbeater
Molbank 2022, 2022(3), M1404; https://doi.org/10.3390/M1404
Received: 23 June 2022 / Revised: 28 June 2022 / Accepted: 28 June 2022 / Published: 7 July 2022
(This article belongs to the Section Organic Synthesis)
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Abstract

The 1,2,3-triazole ring system can be easily obtained by widely used copper-catalyzed click reaction of azides with alkynes. 1,2,3-triazole exhibits myriad of biological activities, including antibacterial antimalarial, and antiviral activities. We herein reported the synthesis of quinoline-based [1,2,3]-triazole hybrid derivative via Cu(I)-catalyzed click reaction of 4-azido-7-chloroquinoline with alkyne derivative of hydroxybenzotriazole (HOBt). The compound was fully characterized by proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), correlated spectroscopy (1H-1H-COSY), heteronuclear single quantum coherence (HSQC) and distortionless enhancement by polarization transfer (DEPT-135 and DEPT-90) NMR, ultraviolet (UV) and Fourier-transform infrared (FTIR) spectroscopies, and high-resolution mass spectrometry (HRMS). Computational studies were enrolled to predict the interaction of the synthesized compound with acetylcholinesterase, a target of primary relevance for developing new therapeutic options to counteract neurodegeneration. Moreover, the drug-likeness of the compound was also investigated by predicting its pharmacokinetic properties. View Full-Text
Keywords: 1,2,3-triazole; drug discovery; acetylcholinesterase; Alzheimer’s disease; molecular docking 1,2,3-triazole; drug discovery; acetylcholinesterase; Alzheimer’s disease; molecular docking
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MDPI and ACS Style

Fai, L.K.; Anyanwu, M.; Ai, J.; Xie, Y.; Gianoncelli, A.; Ribaudo, G.; Coghi, P. 4-(4-(((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-7-chloroquinoline. Molbank 2022, 2022, M1404. https://doi.org/10.3390/M1404

AMA Style

Fai LK, Anyanwu M, Ai J, Xie Y, Gianoncelli A, Ribaudo G, Coghi P. 4-(4-(((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-7-chloroquinoline. Molbank. 2022; 2022(3):M1404. https://doi.org/10.3390/M1404

Chicago/Turabian Style

Fai, Leong Ka, Margrate Anyanwu, Jiang Ai, Yuhan Xie, Alessandra Gianoncelli, Giovanni Ribaudo, and Paolo Coghi. 2022. "4-(4-(((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-7-chloroquinoline" Molbank 2022, no. 3: M1404. https://doi.org/10.3390/M1404

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