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School of Pharmacy, Macau University of Science and Technology, Macau, China
Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy
Authors to whom correspondence should be addressed.
Academic Editor: Nicholas E. Leadbeater
Molbank 2022, 2022(3), M1404;
Received: 23 June 2022 / Revised: 28 June 2022 / Accepted: 28 June 2022 / Published: 7 July 2022
(This article belongs to the Section Organic Synthesis)
The 1,2,3-triazole ring system can be easily obtained by widely used copper-catalyzed click reaction of azides with alkynes. 1,2,3-triazole exhibits myriad of biological activities, including antibacterial antimalarial, and antiviral activities. We herein reported the synthesis of quinoline-based [1,2,3]-triazole hybrid derivative via Cu(I)-catalyzed click reaction of 4-azido-7-chloroquinoline with alkyne derivative of hydroxybenzotriazole (HOBt). The compound was fully characterized by proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), correlated spectroscopy (1H-1H-COSY), heteronuclear single quantum coherence (HSQC) and distortionless enhancement by polarization transfer (DEPT-135 and DEPT-90) NMR, ultraviolet (UV) and Fourier-transform infrared (FTIR) spectroscopies, and high-resolution mass spectrometry (HRMS). Computational studies were enrolled to predict the interaction of the synthesized compound with acetylcholinesterase, a target of primary relevance for developing new therapeutic options to counteract neurodegeneration. Moreover, the drug-likeness of the compound was also investigated by predicting its pharmacokinetic properties. View Full-Text
Keywords: 1,2,3-triazole; drug discovery; acetylcholinesterase; Alzheimer’s disease; molecular docking 1,2,3-triazole; drug discovery; acetylcholinesterase; Alzheimer’s disease; molecular docking
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MDPI and ACS Style

Fai, L.K.; Anyanwu, M.; Ai, J.; Xie, Y.; Gianoncelli, A.; Ribaudo, G.; Coghi, P. 4-(4-(((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-7-chloroquinoline. Molbank 2022, 2022, M1404.

AMA Style

Fai LK, Anyanwu M, Ai J, Xie Y, Gianoncelli A, Ribaudo G, Coghi P. 4-(4-(((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-7-chloroquinoline. Molbank. 2022; 2022(3):M1404.

Chicago/Turabian Style

Fai, Leong Ka, Margrate Anyanwu, Jiang Ai, Yuhan Xie, Alessandra Gianoncelli, Giovanni Ribaudo, and Paolo Coghi. 2022. "4-(4-(((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-7-chloroquinoline" Molbank 2022, no. 3: M1404.

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