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Short Note

11H-Indeno[1,2-b]quinoxalin-11-one 2-(4-ethylbenzylidene)hydrazone

Kizhner Research Center, Tomsk Polytechnic University, 634050 Tomsk, Russia
Scientific Research Institute of Biological Medicine, Altai State University, 656049 Barnaul, Russia
Author to whom correspondence should be addressed.
Academic Editor: Ian R. Baxendale
Molbank 2021, 2021(4), M1299;
Received: 9 October 2021 / Revised: 16 November 2021 / Accepted: 19 November 2021 / Published: 23 November 2021
(This article belongs to the Section Organic Synthesis)
11H-Indeno[1,2-b]quinoxaline derivatives present an important type of nitrogen-containing heterocyclic compound that are useful intermediate products in organic synthesis and have potential pharmaceutical applications. A new 11H-indeno[1,2-b]quinoxalin-11-one-2-(4-ethylbenzylidene)hydrazone (compound 3) was synthesized. Compound 3 is the first example of an azine derivative based on the 11H-indeno[1,2-b]quinoxaline system. The Z,E-isomerism of compound 3 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, compound 3 is potentially highly bioavailable and has potential to be used for the treatment of neuroinflammation and ischemia–reperfusion injury. View Full-Text
Keywords: azine; aldazine; 11H-indeno[1,2-b]quinoxalin-11-one; DFT; ADME azine; aldazine; 11H-indeno[1,2-b]quinoxalin-11-one; DFT; ADME
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MDPI and ACS Style

Kovrizhina, A.R.; Samorodova, E.I.; Khlebnikov, A.I. 11H-Indeno[1,2-b]quinoxalin-11-one 2-(4-ethylbenzylidene)hydrazone. Molbank 2021, 2021, M1299.

AMA Style

Kovrizhina AR, Samorodova EI, Khlebnikov AI. 11H-Indeno[1,2-b]quinoxalin-11-one 2-(4-ethylbenzylidene)hydrazone. Molbank. 2021; 2021(4):M1299.

Chicago/Turabian Style

Kovrizhina, Anastasia R., Elizaveta I. Samorodova, and Andrei I. Khlebnikov 2021. "11H-Indeno[1,2-b]quinoxalin-11-one 2-(4-ethylbenzylidene)hydrazone" Molbank 2021, no. 4: M1299.

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