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4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides

Faculty of Chemistry, University of Plovdiv Paisii Hilendarski, 24 Tsar Asen Str., 4000 Plovdiv, Bulgaria
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Academic Editor: Raffaella Mancuso
Molbank 2021, 2021(3), M1266; https://doi.org/10.3390/M1266
Received: 14 June 2021 / Revised: 23 June 2021 / Accepted: 2 August 2021 / Published: 5 August 2021
(This article belongs to the Section Organic Synthesis)
In a high-yielding and solvent-free procedure N-ethoxycarbonyl protected ω-amino-β-keto anilides undergo Knorr cyclisation in neat polyphosphoric acid to provide straightforward route to 4-aminoalkyl quinolin-2-one derivatives with variable length of the alkyl chain. View Full-Text
Keywords: Knorr; quinolin-2-one; 2-quinolone; carbostyril; solvent-free Knorr; quinolin-2-one; 2-quinolone; carbostyril; solvent-free
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MDPI and ACS Style

Angelov, P.; Velichkova, S.; Yanev, P. 4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides. Molbank 2021, 2021, M1266. https://doi.org/10.3390/M1266

AMA Style

Angelov P, Velichkova S, Yanev P. 4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides. Molbank. 2021; 2021(3):M1266. https://doi.org/10.3390/M1266

Chicago/Turabian Style

Angelov, Plamen, Stilyana Velichkova, and Pavel Yanev. 2021. "4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides" Molbank 2021, no. 3: M1266. https://doi.org/10.3390/M1266

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