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Open AccessCommunication

Microwave-Assisted Synthesis of Schiff Bases of Isoniazid and Evaluation of Their Anti-Proliferative and Antibacterial Activities

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Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, PO BOX 263, Amman 19328, Jordan
2
Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan
3
School of Pharmacy, The University of Jordan, Amman 19328, Jordan
*
Author to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2021, 2021(1), M1189; https://doi.org/10.3390/M1189
Received: 31 December 2020 / Revised: 29 January 2021 / Accepted: 31 January 2021 / Published: 4 February 2021
Three new Schiff bases of isoniazid were synthesized using microwave-assisted synthesis and conventional condensation with aromatic aldehydes. Synthesized compounds were characterized using elemental analysis, IR, NMR, and Mass spectroscopy. Synthesized compounds were evaluated for antiproliferative activity against MCF-7 cell line. The IC50 values were from 125 to 276 µM. The compounds were also evaluated for antibacterial activity against Staphylococcus aureus and Escherichia coli. Results showed that the synthesized compounds produce significant antibacterial activity in vitro. Inhibition of compounds ranged from 13 to 18 mm. View Full-Text
Keywords: Schiff base; isoniazid; antiproliferative; antibacterial; microwave irradiation; MCF-7 cell lines; isonicotinic acid hydrazide; S. aureus; E. coli Schiff base; isoniazid; antiproliferative; antibacterial; microwave irradiation; MCF-7 cell lines; isonicotinic acid hydrazide; S. aureus; E. coli
MDPI and ACS Style

Al-Hiyari, B.A.; Shakya, A.K.; Naik, R.R.; Bardaweel, S. Microwave-Assisted Synthesis of Schiff Bases of Isoniazid and Evaluation of Their Anti-Proliferative and Antibacterial Activities. Molbank 2021, 2021, M1189. https://doi.org/10.3390/M1189

AMA Style

Al-Hiyari BA, Shakya AK, Naik RR, Bardaweel S. Microwave-Assisted Synthesis of Schiff Bases of Isoniazid and Evaluation of Their Anti-Proliferative and Antibacterial Activities. Molbank. 2021; 2021(1):M1189. https://doi.org/10.3390/M1189

Chicago/Turabian Style

Al-Hiyari, Bayan A.; Shakya, Ashok K.; Naik, Rajashri R.; Bardaweel, Sanaa. 2021. "Microwave-Assisted Synthesis of Schiff Bases of Isoniazid and Evaluation of Their Anti-Proliferative and Antibacterial Activities" Molbank 2021, no. 1: M1189. https://doi.org/10.3390/M1189

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