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Ethyl 6-Methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Laboratório de Síntese Orgânica Medicinal (LaSOM®), Faculty of Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Ipiranga Avenue, Porto Alegre, RS 2752, Brazil
Laboratório de Química Medicinal de Compostos de Selênio (QMCSe), Federal University of Health Sciences of Porto Alegre, Sarmento Leite Street, Porto Alegre, RS 245, Brazil
Author to whom correspondence should be addressed.
Molbank 2019, 2019(3), M1076;
Received: 2 July 2019 / Revised: 30 July 2019 / Accepted: 1 August 2019 / Published: 14 August 2019
(This article belongs to the Section Organic Synthesis)
The Biginelli reaction is an acid-catalyzed, three-component reaction between an aldehyde, a hydrogen methylene active compound, and urea (or its analogue) and constitutes a rapid and easy synthesis of highly functionalized heterocycles. Synthesis of ethyl 6-methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate, identified by our laboratory code LaSOM® 293, was achieved using the Biginelli reaction as the key step, followed by the Huisgen 1,3-dipolar cycloaddition in a convergent four-step route. The product LaSOM® 293 was obtained with a yield of 84%. View Full-Text
Keywords: Biginelli reaction; 3,4-dihydropyrimidinone; triazole; LaSOM® 293 Biginelli reaction; 3,4-dihydropyrimidinone; triazole; LaSOM® 293
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MDPI and ACS Style

Gonçalves, I.L.; Azambuja, G.O.; Davi, L.; Gonçalves, G.A.; Kagami, L.P.; Neves, G.M.; Silveira, J.P.; Canto, R.F.S.; Eifler-Lima, V.L. Ethyl 6-Methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate. Molbank 2019, 2019, M1076.

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