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Laboratorio de Síntesis de Heterociclos Bioactivos, Departamento de Farmacia, Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Avda. Vicuña Mackenna 4860, Macul 7820436, Santiago, Chile
Author to whom correspondence should be addressed.
Molbank 2018, 2018(2), M991;
Received: 17 March 2018 / Revised: 13 April 2018 / Accepted: 16 April 2018 / Published: 18 April 2018
(This article belongs to the Special Issue Heterocycles)
PDF [2198 KB, uploaded 18 April 2018]


The title compound was prepared by an aza-Michael addition reaction between 1-[1-(4-chlorobenzenesulfonyl)-1H-indole-3-yl]prop-2-en-1-one and 2-piridylpiperazine catalyzed by SiO2. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR). The compound was assayed in a binding assay at the 5-HT6 receptor, showing poor affinity. View Full-Text
Keywords: aza-Michael addition; indole; serotonin; 5-HT6; arylpiperazine; arylsulfonylindole aza-Michael addition; indole; serotonin; 5-HT6; arylpiperazine; arylsulfonylindole

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Diethelm, B.; Almendras, S.; Recabarren-Gajardo, G. 1-[1-(4-Chlorobenzenesulfonyl)-1H-indole-3-yl]-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-1-one. Molbank 2018, 2018, M991.

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