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(Z)-4-[2-(3,4-Difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one

1
Department of Chemistry, P.A. College of Engineering, Nadupadavu 574153, Mangaluru, Karnataka, India
2
Department of Industrial Chemistry, Mangalore University, Mangalagangothri 574199, Mangaluru, Karnataka, India
3
Department of Studies in Chemistry, Mangalore University, Mangalagangothri 574199, Mangaluru, Karnataka, India
4
Department of Pharmacology and Yenepoya Research Centre, Yenepoya-Deemed to be University, Deralakatte 574153, Mangaluru, Karnataka, India
*
Author to whom correspondence should be addressed.
Molbank 2018, 2018(2), M989; https://doi.org/10.3390/M989
Received: 24 February 2018 / Revised: 20 March 2018 / Accepted: 29 March 2018 / Published: 31 March 2018
(This article belongs to the Special Issue Heterocycles)
The title compound (Z)-4-[2-(3,4-difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one 4 was synthesized by the reaction of ethyl 2-[2-(3,4-difluorophenyl)hydrazono]-3-oxobutanoate 3 with hydrazine hydrate. The diazotization of 3,4-difluoroaniline, followed by the treatment with ethyl acetoacetate, afforded intermediate 3. The synthesized compound 4 was characterized by FTIR, 1H-NMR, 13C-NMR and LCMS, and it showed synergistic anti-inflammatory, antiproliferative and antibacterial activities. View Full-Text
Keywords: pyrazol-5(4H)-one; hydrazine hydrate; anti-inflammatory; antiproliferative; antibacterial activity pyrazol-5(4H)-one; hydrazine hydrate; anti-inflammatory; antiproliferative; antibacterial activity
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MDPI and ACS Style

Mohan, B.J.; Sarojini, B.K.; Narayana, B.; Sindhu Priya, E.S. (Z)-4-[2-(3,4-Difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one. Molbank 2018, 2018, M989.

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