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Open AccessCommunication

A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride

1
Lomonosov Institute of Fine Chemical Technologies, Moscow Technological University, Vernadsky ave. 86, 119571 Moscow, Russia
2
Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev ave. 8, 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Molbank 2018, 2018(1), M981; https://doi.org/10.3390/M981
Received: 22 January 2018 / Revised: 12 February 2018 / Accepted: 16 February 2018 / Published: 18 February 2018
(This article belongs to the Section Organic Synthesis)
The absence of highly effective delivery systems is a major challenge for gene therapy. Our work was aimed at the development of novel cationic liposomes possessing high transfection efficiency. For this purpose, a novel disulfide polycationic amphiphile 2S4 was synthesized. Cationic liposomes based on 2S4 and a helper lipid DOPE were formed by the thin film hydration method and exhibited effective plasmid DNA delivery into the HEK293 cells, with a transfection activity superior to that of the commercial agent Lipofectamine® 2000. Our results suggest that the polycationic amphiphile 2S4 is a promising candidate for in vitro nucleic acid delivery. View Full-Text
Keywords: redox-sensitive; disulfide linker; gemini amphiphiles; cationic liposomes; gene therapy redox-sensitive; disulfide linker; gemini amphiphiles; cationic liposomes; gene therapy
MDPI and ACS Style

Puchkov, P.A.; Shmendel, E.V.; Andreeva, V.D.; Morozova, N.G.; Zenkova, M.A.; Maslov, M.A. A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride. Molbank 2018, 2018, M981.

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