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Ethyl 2-[2-(4-Nitrobenzoyl)-1H-indol-3-yl]acetate

Department of Chemistry, Kyonggi University,154-42, Gwanggyosan-ro, Yeongtong-gu, Suwon 16227, Korea
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Molbank 2017, 2017(3), M945; https://doi.org/10.3390/M945
Received: 30 June 2017 / Revised: 7 July 2017 / Accepted: 7 July 2017 / Published: 12 July 2017
(This article belongs to the Section Organic Synthesis)
Ethyl 2-[2-(4-nitrobenzoyl)-1H-indol-3-yl]acetate was prepared in good yield and characterized by the aza-alkylation/intramolecular Michael cascade reaction of (E)-ethyl 3-[2-(tosylamino)phenyl]acrylate with 2-bromo-4′′-nitroacetophenone, followed by desulfonative dehydrogenation with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) The structure of the newly synthesized compound was determined using 1H-,13C-NMR, IR and mass spectral data. View Full-Text
Keywords: Indole; Michael reaction; dehydrogenation; cascade reaction Indole; Michael reaction; dehydrogenation; cascade reaction
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MDPI and ACS Style

Choi, S.; Kim, S.-G. Ethyl 2-[2-(4-Nitrobenzoyl)-1H-indol-3-yl]acetate. Molbank 2017, 2017, M945.

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