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Molbank 2017, 2017(2), M941;


Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany
Center of Pharmaceutical Engeneering (PVZ), Technische Universität Braunschweig, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany
Author to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Received: 6 March 2017 / Revised: 24 March 2017 / Accepted: 27 March 2017 / Published: 7 April 2017
(This article belongs to the Section Organic Synthesis)
Full-Text   |   PDF [504 KB, uploaded 7 April 2017]


The title compound was prepared by electrophilic aromatic substitution of 7-bromo-1-methyl-2-phenyl-1H-indole with NCTS (N-cyano-N-phenyl-p-toluenesulfonamide). The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR, APCI-MS). Purity was assessed by two independent HPLC methods. View Full-Text
Keywords: electrophilic aromatic substitution; indole; NCTS; nitrile; protein kinase inhibitor electrophilic aromatic substitution; indole; NCTS; nitrile; protein kinase inhibitor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Meine, R.; Blech, M.; Lindhof, J.; Kunick, C. 7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile. Molbank 2017, 2017, M941.

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