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2,3,4,9-Tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one

School of Pharmacy, Hyogo University of Health Sciences, 1-3-6, Minatojima, Chuo-ku, Kobe, 650-8530, Japan
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Molbank 2015, 2015(1), M841; https://doi.org/10.3390/M841
Received: 16 December 2014 / Revised: 23 January 2015 / Accepted: 27 January 2015 / Published: 30 January 2015
The title compound 2,3,4,9-tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one (5) was obtained by the nucleophilic addition of 2-hydroxy-1,4-naphthoquinone (4) to 2H-chromene derivative 3, which was prepared by the domino three-component coupling reaction of aryne precursor 1 with DMF and the active methylene compound dimedone (2). The one-pot synthesis of the title compound 5 from aryne precursor 1 was also achieved. View Full-Text
Keywords: multi-component reaction; domino reaction; arynes; heterocycles; synthesis multi-component reaction; domino reaction; arynes; heterocycles; synthesis
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Yoshioka, E.; Kohtani, S.; Miyabe, H. 2,3,4,9-Tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one. Molbank 2015, 2015, M841.

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