N'-[2-(7,8-Dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethylidene]-4-nitrobenzohydrazide
by
Masayuki Morikawa, Katsuhito Kino *, Eriko Asada, Kosuke Katagiri, Kanami Mori-Yasumoto, Masayo Suzuki, Takanobu Kobayashi and Hiroshi Miyazawa
Masayuki Morikawa, Katsuhito Kino *, Eriko Asada, Kosuke Katagiri, Kanami Mori-Yasumoto, Masayo Suzuki, Takanobu Kobayashi and Hiroshi Miyazawa
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan
*
Author to whom correspondence should be addressed.
Molbank 2014, 2014(4), M836; https://doi.org/10.3390/M836
Received: 6 August 2014 / Accepted: 23 October 2014 / Published: 28 October 2014
The title compound, N'-[2-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin- 10(2H)-yl)ethylidene]-4-nitrobenzohydrazide (1), was obtained by the reaction of formylmethylflavin and p-nitrobenzohydrazide. The product 1 inhibited the DNA binding of nuclear factor-κB, and was characterized by 1H-NMR, 13C-NMR, electrospray ionization mass spectrometry, elemental analysis, IR and UV.
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Keywords:
flavin; Nuclear factor-κB; inhibitor; DNA binding
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MDPI and ACS Style
Morikawa, M.; Kino, K.; Asada, E.; Katagiri, K.; Mori-Yasumoto, K.; Suzuki, M.; Kobayashi, T.; Miyazawa, H. N'-[2-(7,8-Dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethylidene]-4-nitrobenzohydrazide. Molbank 2014, 2014, M836.
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