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Volume 2005
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10.3390/M407
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Short Note

4-Methyl-N-(5-methyl-furan-2-ylmethyl)-benzenesulfonamide (N-(5-Methyl-furfuryl)-p-toluenesulfonamide)

by
Holger Meining
and
Baldur Föhlisch
*
Institut für Organische Chemie der Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany
*
Author to whom correspondence should be addressed.
Molbank 2005, 2005(2), M407; https://doi.org/10.3390/M407
Submission received: 8 March 2004 / Accepted: 18 March 2004 / Published: 1 August 2005
Versions Notes

Molbank 2005 m407 i001
5-Methylfurfurylamine was prepared from commercially available 5-methylfurfural via the oxime, followed by LiAlH4 reduction [1]. A solution of 5-methylfurfurylamine (12.2 g, 100 mmol) in tert-butylmethyl ether[2] (MTBE, 50 mL) was made in a 250-mL four-necked flask, fitted with two dropping funnels and an immersion thermometer, and cooled in an ice/salt bath to -15 °C. With vigorous stirring, solutions of p-toluenesulfonyl chloride (20.97 g, 110 mmol) in MTBE (80 mL) and 20% aqueous sodium hydroxide (22 mL, 110 mmol) were added simultaneously and cautiously. The temperatur of the reaction mixture was not allowed to exceed –5 °C. When the addition was completed (60–90 min), the cooling bath was removed, and the mixture stirred for 2–3 hours. The MTBE layer was separated, and the aqueous layer acidified to pH 3–4 and extracted with MTBE (4 ’ 40 mL). The combined organic solutions were washed with saturated brine (2 ’ 40 mL) and dried overnight with magnesium sulfate. After filtration, the solvent was removed in a rotary evaporator. The remaining pale yellow oil solidified in a refrigerator. This raw product was recrystallized from ethanol/pentane (1:1 v/v, 150 mL) to yield 23.44 g (88%) of a colourless crystalline solid.
Melting Point: 82.5–83.5 °C [3].
1H-NMR (250 MHz, CDCl3): δ= 2.11 (s, 3 H, 5-CH3); 2.41 (s, 3 H, CH3C6H4SO2); 4.10 (d, J = 5.9 Hz, 2 H, CH2-N); 4.98 (t, J = 5.9 Hz, 1 H, NH); AB sub-spectrum with δ A = 5.95, δ B = 5.76, JAB = 3.1 Hz, the B part is split (5 lines, 2 H, H-3 and H-4); AA’BB’ sub-spectrum with δ A = 7.71, δ B = 7.26, JAB = 8.0 Hz, (4 H, H-2/6 of CH3C6H4SO2, HAA’ and H-3/5 of CH3C6H4SO2, HBB’).
13C-NMR (62.9 MHz, CDCl3): δ= 12.3 (5-CH3); 20.5 (CH3C6H4SO2); 39.2 (CH2-N); 105.15 (C-4); 108.1 (C-3); 126.1 (Tos-C-2/6); 128.5 (Tos-C-3/5); 136.0 (Tos-C-4); 142.3 (Tos-C-1); 146.6 (C-5); 151.2 (C-2).
IR (CHCl3 film, cm-1): 3380, 3280 (NH); 2930, 2880 (C-H); 1598 (C=C); 1555, 1492, 1410, 1330, 1160 cm-1 (SO2).
Elemental Analysis: Calculated for C13H15NO3S (265.3): C, 58.85%; H, 5.70%; N, 5.28%; S, 12.08%. Found: C, 58.61%; H, 5.68%; N, 5.24%; S 12.03%.

Supplementary materials

Supplementary File 1Supplementary File 2Supplementary File 3

References and Notes

  1. a) Mndzhoian, A. L.; Afrikian, V. G.; Khorenian, G. A. Izv. Akad. Nauk. Arm. SSR Khim. Nauki 1961, 14, 363–368, Chem. Abstr. 1962, 57, 11136g. b) Mndzhoian, A. L. Synthesis of Heterocyclic Compounds; Consultants Bureau: London, 1959; Vol. 2, p. 60. [Google Scholar]
  2. tert-Butylmethyl ether was recommended as an inexpensive solvent when this experiment was carried out (June 1991, Diploma thesis of H.M.). Nowadays, it is considered environmentally problematic. We also used 1,2-dichloroethane instead of the ether.
  3. For a more expensive micro-scale preparation with selective annihilation of contaminants (‘impurity annihilation’), see: Barrett, A. G. M.; Smith, M. L.; Zecri, F. J. J. Chem. Soc., Chem. Commun. 1998, 2317–2318. However, physical data and combustion analysis are not given in this paper.
  • Sample Availability: Available from MDPI.

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MDPI and ACS Style

Meining, H.; Föhlisch, B. 4-Methyl-N-(5-methyl-furan-2-ylmethyl)-benzenesulfonamide (N-(5-Methyl-furfuryl)-p-toluenesulfonamide). Molbank 2005, 2005, M407. https://doi.org/10.3390/M407

AMA Style

Meining H, Föhlisch B. 4-Methyl-N-(5-methyl-furan-2-ylmethyl)-benzenesulfonamide (N-(5-Methyl-furfuryl)-p-toluenesulfonamide). Molbank. 2005; 2005(2):M407. https://doi.org/10.3390/M407

Chicago/Turabian Style

Meining, Holger, and Baldur Föhlisch. 2005. "4-Methyl-N-(5-methyl-furan-2-ylmethyl)-benzenesulfonamide (N-(5-Methyl-furfuryl)-p-toluenesulfonamide)" Molbank 2005, no. 2: M407. https://doi.org/10.3390/M407

APA Style

Meining, H., & Föhlisch, B. (2005). 4-Methyl-N-(5-methyl-furan-2-ylmethyl)-benzenesulfonamide (N-(5-Methyl-furfuryl)-p-toluenesulfonamide). Molbank, 2005(2), M407. https://doi.org/10.3390/M407

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