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Int. J. Mol. Sci. 2007, 8(2), 136-144;

Interactions between Cytochrome c and DNA Strands Self-Assembled at Gold Electrode

Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
Tianjin University of Science and Technology, Tianjin 300040, China
Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, China
Author to whom correspondence should be addressed.
Received: 29 November 2006 / Accepted: 29 January 2007 / Published: 23 February 2007
(This article belongs to the Special Issue Interaction of Biological Molecules)
Full-Text   |   PDF [153 KB, uploaded 19 June 2014]


In this work, we reported the investigation on the interaction between DNAstrands self-assembled at gold electrodes and an electron transfer protein, cytochrome c. Weobserved that cytochrome c exhibited well-defined electrochemistry in both double-strandedand single-stranded DNA films. This suggested that the electron transfer reaction ofcytochrome c arose possibly due to the electron hopping along DNA strands rather thanwiring along the double helix. We also compared the heterogeneous electron transfer rate ofcytochrome c with that of a ruthenium complex, which further confirmed this mechanism. View Full-Text
Keywords: Cytochrome c; DNA; electrochemistry; gold electrodes; cyclic voltammetry Cytochrome c; DNA; electrochemistry; gold electrodes; cyclic voltammetry
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lao, R.; Wang, L.; Wan, Y.; Zhang, J.; Song, S.; Zhang, Z.; Fan, C.; He, L. Interactions between Cytochrome c and DNA Strands Self-Assembled at Gold Electrode. Int. J. Mol. Sci. 2007, 8, 136-144.

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