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Volume 27
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10.3390/ijms27083392
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

PRDM Proteins Orchestrate Colorectal Cancer Tumorigenesis

by
Erika Di Zazzo
1,
Carmela Sorrentino
2,
Monica Rienzo
3,*,
Donatella Fiore
4,
Maria Chiara Proto
5,
Amelia Casamassimi
2,
Patrizia Gazzerro
4 and
Ciro Abbondanza
2
1
Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy
2
Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
3
Department of Environmental, Biological, and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, 81100 Caserta, Italy
4
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
5
Department of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2026, 27(8), 3392; https://doi.org/10.3390/ijms27083392
Submission received: 6 March 2026 / Revised: 2 April 2026 / Accepted: 7 April 2026 / Published: 9 April 2026
(This article belongs to the Special Issue Molecular Research on PRDM Genes)
Versions Notes

Abstract

Colorectal cancer (CRC) is a heterogeneous disease driven by complex genetic, epigenetic, and microenvironmental alterations. Members of the PR domain-containing (PRDM) protein family have emerged as context-dependent regulators of CRC initiation, progression, tumor cell plasticity, immune modulation, and therapeutic response. Accumulating evidence highlights divergent roles for PRDM proteins as tumor suppressors, oncogenes, or isoform-dependent dual-function regulators. Collectively, PRDM family members represent a central node of transcriptional/epigenetic control in CRC biology, with significant potential as biomarkers for early detection, prognosis, and treatment stratification, as well as promising candidates for epigenetic and pathway-directed therapeutic strategies.
Keywords: colorectal cancer; PRDM; cancer biomarkers; oncogene; tumor suppressor; consensus molecular subtypes (CMS) colorectal cancer; PRDM; cancer biomarkers; oncogene; tumor suppressor; consensus molecular subtypes (CMS)

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MDPI and ACS Style

Di Zazzo, E.; Sorrentino, C.; Rienzo, M.; Fiore, D.; Proto, M.C.; Casamassimi, A.; Gazzerro, P.; Abbondanza, C. PRDM Proteins Orchestrate Colorectal Cancer Tumorigenesis. Int. J. Mol. Sci. 2026, 27, 3392. https://doi.org/10.3390/ijms27083392

AMA Style

Di Zazzo E, Sorrentino C, Rienzo M, Fiore D, Proto MC, Casamassimi A, Gazzerro P, Abbondanza C. PRDM Proteins Orchestrate Colorectal Cancer Tumorigenesis. International Journal of Molecular Sciences. 2026; 27(8):3392. https://doi.org/10.3390/ijms27083392

Chicago/Turabian Style

Di Zazzo, Erika, Carmela Sorrentino, Monica Rienzo, Donatella Fiore, Maria Chiara Proto, Amelia Casamassimi, Patrizia Gazzerro, and Ciro Abbondanza. 2026. "PRDM Proteins Orchestrate Colorectal Cancer Tumorigenesis" International Journal of Molecular Sciences 27, no. 8: 3392. https://doi.org/10.3390/ijms27083392

APA Style

Di Zazzo, E., Sorrentino, C., Rienzo, M., Fiore, D., Proto, M. C., Casamassimi, A., Gazzerro, P., & Abbondanza, C. (2026). PRDM Proteins Orchestrate Colorectal Cancer Tumorigenesis. International Journal of Molecular Sciences, 27(8), 3392. https://doi.org/10.3390/ijms27083392

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