Polyphenol Intake in Elderly Patients: A Novel Approach to Counteract Colorectal Cancer Risk?
Abstract
1. Epidemiology and Risks Factors of Colorectal Cancer
2. Molecular Basis of Colorectal Cancer and Chromosomal Instability
3. Inflammatory Bowel Disease and CRC
4. Management of CRC
5. CRC in Elderly Patients
6. Polyphenols and Their Role in CRC Prevention
7. Research Methodology
8. Polyphenols for CRC Prevention: Preclinical Studies
8.1. Flavonoids
8.1.1. Quercetin
8.1.2. Kaempferol
8.1.3. Anthocyanin
8.1.4. Genistein
8.1.5. Epigallocatechin-3-Gallate
8.2. Non-Flavonoid Polyphenol
8.2.1. Resveratrol
8.2.2. Phenolic Acid and Derivates
8.2.3. Curcumin
8.3. Terpenoids
8.3.1. Betulinic Acid
8.3.2. Ursolic Acid
8.4. Organosulfur
9. Polyphenol Intake to Prevent CRC in Elderly Population: Clinical Studies
10. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Polyphenols | Study Subject | Dose and Duration | Main Outcome | References |
---|---|---|---|---|
EGCG | 32 adult patients with high risk for CRC | 200 mg for 6 weeks |
| [173] |
Resveratrol | 20 adult patients with resectable CRC | 0.5 g or 1 g for 8 days |
| [174] |
Curcumin | 126 adult patients with CRC | 360 mg for 10–30 days |
| [176] |
Curcumin + Anthocyanin | 45 adult patients with colorectal adenomatous polyps | 500 mg (Curcumin) and 500 mg (anthocyanin) for 4–6 weeks |
| [177] |
Curcumin + Anthocyanin | 35 adult patients with adenomatous polyps | 500 mg (Curcumin) and 500 mg (anthocyanin) for 4–6 weeks |
| [178] |
Genistein + FOLFOX | 13 adult patients with metastatic CRC | Genistein combined with FOLFOX 60 mg/day orally for 7 days every 2 weeks |
| [179] |
Ellagitannins + Ellagic acid | 35 adult patients with CRC | 900 mg for 5–35 days |
| [180] |
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Fumarola, S.; Cianfruglia, L.; Cecati, M.; Giammarchi, C.; Vaiasicca, S.; Gasparrini, M. Polyphenol Intake in Elderly Patients: A Novel Approach to Counteract Colorectal Cancer Risk? Int. J. Mol. Sci. 2025, 26, 2497. https://doi.org/10.3390/ijms26062497
Fumarola S, Cianfruglia L, Cecati M, Giammarchi C, Vaiasicca S, Gasparrini M. Polyphenol Intake in Elderly Patients: A Novel Approach to Counteract Colorectal Cancer Risk? International Journal of Molecular Sciences. 2025; 26(6):2497. https://doi.org/10.3390/ijms26062497
Chicago/Turabian StyleFumarola, Stefania, Laura Cianfruglia, Monia Cecati, Cinzia Giammarchi, Salvatore Vaiasicca, and Massimiliano Gasparrini. 2025. "Polyphenol Intake in Elderly Patients: A Novel Approach to Counteract Colorectal Cancer Risk?" International Journal of Molecular Sciences 26, no. 6: 2497. https://doi.org/10.3390/ijms26062497
APA StyleFumarola, S., Cianfruglia, L., Cecati, M., Giammarchi, C., Vaiasicca, S., & Gasparrini, M. (2025). Polyphenol Intake in Elderly Patients: A Novel Approach to Counteract Colorectal Cancer Risk? International Journal of Molecular Sciences, 26(6), 2497. https://doi.org/10.3390/ijms26062497