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Volume 26
Issue 5
10.3390/ijms26052367
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Article
Peer-Review Record

Polyethylene Glycol Loxenatide Accelerates Diabetic Wound Healing by Downregulating Systemic Inflammation and Improving Endothelial Progenitor Cell Functions

Int. J. Mol. Sci. 2025, 26(5), 2367; https://doi.org/10.3390/ijms26052367
by Zerui Ding 1,†, Chunru Yang 1,†, Xiaojun Zhai 1, Yuqi Xia 1, Jieying Liu 1,2,* and Miao Yu 1,*
Reviewer 1: Anonymous
Reviewer 2:
Eric De Souza Gil
Int. J. Mol. Sci. 2025, 26(5), 2367; https://doi.org/10.3390/ijms26052367
Submission received: 8 February 2025 / Revised: 25 February 2025 / Accepted: 4 March 2025 / Published: 6 March 2025
(This article belongs to the Section Molecular Endocrinology and Metabolism)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

1. This is a wonderful experimental work with substantial original data. Is PEG-loxe only for the diabetic wound healing, or can the authors extrapolate these results to any wound healing?

2. About the diabetes, especially type 2 diabetes, WFS1 gene is one of the main risk factors in humans. This gene is related to the regulation of growth hormone and to the mitochondrial functions and metabolism (PMID: 19293327, 37759745).

3. What about innate immunity signals in the skin, like GPR15 (PMID: 26348578). GPR15 is upregulated in psoriasis and leads to the wound healing problems in psoriasis, hyperkeratosis and hyperactive skin. The authors mention IL10 and some other cytokines, but GPR15 should also be discussed. And some more psoriasis-related studies like a large transcriptional profiling study (PMID: 25897967) and IL-20 related connections (PMID: 14712309).

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

The paper is very clear and consistent. In abstracts, the authors have used abreviations for everything, except for the mediators: HIF-1α, VEGFα and SDF-1. Also, the abreviation used for high glucose and palmitic acid condition (HP) is not didatical.

It is not didatical, to use 8 subchapters (2.1 to 2.8) for results, whereas for discussion, it was used only 2 (3.1 and 3.2). In same way,  the results chapters have used a different construction, than the one used for discussions. For instance, for results "2.1. PEG-loxe improved glucose metabolism"active noun + paste tense verb + passive subject". Already for discussion, it were used only nouns, i.e. "Systemic anti-inflammatory regulation and vascular repair"

The conclusion section was missed.

In line 164, I would ask if the notable effect of PEG-loxe on NO levels was statistically significant?

The figures must have the resolution improved

Some few typing mistakes, i.e glued words with [ref], lines 45, 53 and 68.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Comments and Suggestions for Authors

The authors have addressed all my comments.

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