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Review
Peer-Review Record

Exploring Asthma as a Protective Factor in COVID-19 Outcomes

Int. J. Mol. Sci. 2025, 26(4), 1678; https://doi.org/10.3390/ijms26041678
by Anthony E. Quinn 1,†, Lei Zhao 2,†, Scott D. Bell 1, Muhammad H. Huq 1 and Yujiang Fang 1,3,4,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2025, 26(4), 1678; https://doi.org/10.3390/ijms26041678
Submission received: 19 January 2025 / Revised: 13 February 2025 / Accepted: 14 February 2025 / Published: 16 February 2025
(This article belongs to the Special Issue Molecular Pathophysiology of Lung Diseases)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The work of Quinn et al. is a mini review that Explores asthma as a protective factor in COVID-19 outcomes. The Ms is clearly written, concise with appropriate considerations on the possible protective mechanisms that asthmatic patients might display that make them more resistant to COVID-19. The work might be of interest for the broad readership of Int. J. Mol. Sci.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

The review is based on a current topic, using new research findings. The review analyzes the impact of asthma on patients infected with SARS-CoV-2 and the risk of severe infection. It provides data on the overall protective effect against SARS-CoV-2 infection through various mechanisms, including eosinophilia, inhaled steroid use, reduced ACE expression, and the dominance of type 2 inflammation in asthma.

I missed several important questions that would be of interest to readers: the effect of SARS-CoV-2 vaccines and biologics on the severity of COVID-2019 in asthma. It would be desirable to supplement the review in these aspects.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

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