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Volume 26
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10.3390/ijms262311278
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Targeting Lactylation for Cancer: Mechanisms, Effects, and Therapeutic Prospects

by
Dong Chang
†,
Daolong Li
†,
Yuxi Sun
,
Jiekang Shi
,
Shengping Zhang
* and
Chuangui Wang
*
Biomedical Research Institute, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2025, 26(23), 11278; https://doi.org/10.3390/ijms262311278
Submission received: 25 October 2025 / Revised: 18 November 2025 / Accepted: 20 November 2025 / Published: 21 November 2025
(This article belongs to the Special Issue Molecular Biology of Cancer—Implications for Diagnosis and Treatment: 3rd Edition)
Versions Notes

Abstract

Recent studies reveal that lysine lactylation plays a pivotal and multifaceted role in tumor progression. Here, we provide a systematic overview of the mechanisms underlying lactylation, highlighting its regulation of tumor metabolic reprogramming and immune microenvironment remodeling. We further summarize how lactylation drives malignancy across diverse cancer types and discuss emerging strategies to therapeutically target lactylation in cancer. By integrating current findings, this review offers a comprehensive framework for understanding lactylation in tumor biology and identifies key gaps for future investigation, thereby providing a valuable reference for both basic research and therapeutic development.
Keywords: lactate; lactylation; metabolic; immune microenvironment; tumor lactate; lactylation; metabolic; immune microenvironment; tumor

Share and Cite

MDPI and ACS Style

Chang, D.; Li, D.; Sun, Y.; Shi, J.; Zhang, S.; Wang, C. Targeting Lactylation for Cancer: Mechanisms, Effects, and Therapeutic Prospects. Int. J. Mol. Sci. 2025, 26, 11278. https://doi.org/10.3390/ijms262311278

AMA Style

Chang D, Li D, Sun Y, Shi J, Zhang S, Wang C. Targeting Lactylation for Cancer: Mechanisms, Effects, and Therapeutic Prospects. International Journal of Molecular Sciences. 2025; 26(23):11278. https://doi.org/10.3390/ijms262311278

Chicago/Turabian Style

Chang, Dong, Daolong Li, Yuxi Sun, Jiekang Shi, Shengping Zhang, and Chuangui Wang. 2025. "Targeting Lactylation for Cancer: Mechanisms, Effects, and Therapeutic Prospects" International Journal of Molecular Sciences 26, no. 23: 11278. https://doi.org/10.3390/ijms262311278

APA Style

Chang, D., Li, D., Sun, Y., Shi, J., Zhang, S., & Wang, C. (2025). Targeting Lactylation for Cancer: Mechanisms, Effects, and Therapeutic Prospects. International Journal of Molecular Sciences, 26(23), 11278. https://doi.org/10.3390/ijms262311278

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